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Wildebeest-associated malignant catarrhal fever (WA-MCF), a fatal disease of cattle caused by alcelaphine herpesvirus 1 (AlHV-1), is one of the most important seasonal diseases of cattle in wildebeest endemic areas, with annual incidence reaching 10%. Here we report efficacy of over 80% for a vac...


Cook, Elizabeth A.J.Russell, GeorgeGrant, DawnMutisya, Christine N.Omoto, LazarusDobson, ElizabethLankester, FelixNene, Vishvanath[A randomised vaccine field trial in Kenya demonstrates protection against wildebeest-associated malignant catarrhal fever in cattle]A randomised vaccine field trial in Kenya demonstrates protection against wildebeest-associated malignant catarrhal fever in cattle

The intracellular protozoan parasite Theileria parva transforms bovine lymphocytes inducing uncontrolled proliferation. Proteins released from the parasite are assumed to contribute to phenotypic changes of the host cell and parasite persistence. With 85 members, genes encoding subtelomeric varia...


Schmuckli-Maurer, J.Casanova, C.S.Affentranger, S.Kang'a, S.Nene, VishvanathKatzer, F.McKeever, Declan J.Müller, JoachimBishop, Richard P.Arnab Pain, A.Dobbelaere, D.A.E.[Expression analysis of the Theileria parva Subtelomere-encoded Variable Secreted Protein gene family]Expression analysis of the Theileria parva Subtelomere-encoded Variable Secreted Protein gene family

We present complete sequences of the mitochondrial genomes for two important mosquitoes, Aedes aegypti and Culex quinquefasciatus, that are major vectors of dengue virus and lymphatic filariasis, respectively. The A. aegypti mitochondrial genome is 16,655 bp in length and that of Culex quinquefas...


Behura, S.K.Lobo, N.F.Haas, B.Bruyn, B. deLovin, D.D.Shumway, M.F.Puiu, D.Romero Severson, J.Nene, VishvanathSeverson, D.W.[Complete sequences of mitochondria genomes of Aedes aegypti and Culex quinquefasciatus and comparative analysis of mitochondrial DNA fragments inserted in the nuclear genomes]Complete sequences of mitochondria genomes of Aedes aegypti and Culex quinquefasciatus and comparative analysis of mitochondrial DNA fragments inserted in the nuclear genomes

In this study, we investigated the immunological effects of bovine heat shock protein 70 (HSP70) on the major Theileria sergenti surface protein (p33). The gene encoding p33 was expressed as a fusion protein with bovine HSP70 from a plasmid vector. The adjuvant function of HSP70 on p33 was evalua...


Jeong, W.Kweon, C.H.Kwang, S.W.Hu Suk LeeXu, Y.Lu, C.Zhang, S.Nene, Vishvanath[Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein, p33, of Theileria sergenti]Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein, p33, of Theileria sergenti

Resistance or susceptibility of the snail host Biomphalaria glabrata to Schistosoma mansoni is determined by the genetics of both the snail and parasite. Although Mendelian genetics governs adult resistance to infection, juvenile resistance and susceptibility are complex traits. In this study, su...


Ittiprasert, W.Miller, A.Myers, J.Nene, VishvanathEl-Sayed, N.M.Knight, M.[Identification of immediate response genes dominantly expressed in juvenile resistant and susceptible Biomphalaria glabrata snails upon exposure to Schistosoma mansoni]Identification of immediate response genes dominantly expressed in juvenile resistant and susceptible Biomphalaria glabrata snails upon exposure to Schistosoma mansoni

Polymorphic, multicopy gene families are frequently located in subtelomeric regions of the genomes of parasitic protozoa. Theileria parva telomere-associated (TA) DNA from two chromosomes contained long open reading frames (ORFs) 54% identical at the N-termini whose ends were 2670 and 2680 bp fro...


Bishop, Richard P.Gobright, E.I.Nene, VishvanathMorzaria, S.P.Musoke, A.J.Sohanpal, B.K.[Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres]Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres

Theileria are economically important, intra-cellular protozoa, transmitted by ixodid ticks, which infect wild and domestic ruminants. In the mammalian host, parasites infect leukocytes and erythrocytes. In the arthropod vector they develop in gut epithelial cells and salivary glands. All four int...


Bishop, Richard P.Musoke, A.J.Morzaria, S.P.Gardner, M.Nene, Vishvanath[Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks]Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks

We have previously reported on characterisation of mitochondrial DNA (mtDNA) of Theileria parva (1), an intracellular protozoan parasite of cattle (reviewed in (2). The mtDNA encodes ORFs for apocytochrome b and polypeptides I and III and cytochrome oxidase, contains fragmented rRNA genes and exi...


Shukla, G.C.Nene, Vishvanath[Telomeric features of Theileria parva mitochondrial DNA derived from cycle sequence data of total genomic DNA]Telomeric features of Theileria parva mitochondrial DNA derived from cycle sequence data of total genomic DNA
Morzaria, S.P.Katende, J.M.Kairo, A.Nene, VishvanathMusoke, A.J.[New methods for the diagnosis of Babesia bigemina infection]New methods for the diagnosis of Babesia bigemina infection

When compared with other Apicomplexan organisms. Theileria parva has an execptionally small, 10-12 Mbp. genome. There are only 4 chromosomes, each in the Mbp range, and a complete physical map, based on SfiI linking data, is available for each one. A number of genes and cDNAs have been mapped to ...


Nene, VishvanathMorzaria, S.P.Bishop, Richard P.[Organisation and informational content of the Theileria parva genome]Organisation and informational content of the Theileria parva genome

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