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Background Although vector control strategies, such as insecticide-treated bed nets (ITNs) and indoor residual spraying (IRS) have been effective in Kenya the transmission of malaria continues to afflict western Kenya. This residual transmission is driven in part by Anopheles arabiensis, known fo...


Lozano-Fuentes, SaulKading, R.C.Hartman, D.A.Okoth, Edward A.Githaka, Naftaly W.Nene, VishvanathPoche, R.M.[Evaluation of a topical formulation of eprinomectin against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions]Evaluation of a topical formulation of eprinomectin against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions

Svitek, NicholasSaya, R.Awino, EliasGilbert, S.C.Poole, Elizabeth J.Nene, VishvanathSteinaa, Lucilla[Immunogenicity and protection of the Theileria parva CTL antigen Tp1, with or without a leader sequence, using HAd5/MVA prime-boost vaccination]Immunogenicity and protection of the Theileria parva CTL antigen Tp1, with or without a leader sequence, using HAd5/MVA prime-boost vaccination
Svitek, NicholasSaya, R.Awino, EliasMunyao, S.Njoroge, T.Gilbert, S.Nene, VishvanathSteinaa, Lucilla[Evaluating the Ad5/MVA antigen delivery systems]Evaluating the Ad5/MVA antigen delivery systems

The size and repetitive nature of the Rhipicephalus microplus genome makes obtaining a full genome sequence fiscally and technically problematic. To selectively obtain gene-enriched regions of this tick's genome, Cot filtration was performed, and Cot-filtered DNA was sequenced via 454 FLX pyroseq...


Guerrero, F.D.Moolhuijzen, P.Peterson, D.G.Bidwell, S.Caler, E.Bellgard, M.Nene, VishvanathDjikeng, Appolinaire[Reassociation kinetics-based approach for partial genome sequencing of the cattle tick, Rhipicephalus (Boophilus) microplus]Reassociation kinetics-based approach for partial genome sequencing of the cattle tick, Rhipicephalus (Boophilus) microplus
Heekin, A.M.Guerrero, F.D.Bendele, K.G.Saldivar, L.Scoles, Glen A.Gondro, C.Nene, VishvanathDjikeng, AppolinaireBrayton, K.A.[Analysis of Babesia bovis infection-induced gene expression changes in larvae from the cattle tick, Rhipicephalus (Boophilus) microplus]Analysis of Babesia bovis infection-induced gene expression changes in larvae from the cattle tick, Rhipicephalus (Boophilus) microplus

Tick-borne diseases (TBDs) are a major economic constraint to livestock production in sub-Saharan Africa. ILRI is focussing on developing a range of products, such as vaccines, diagnostics and decision support services to underpin improved control programmes against these diseases. We have develo...


Morzaria, S.P.Katende, J.Musoke, A.J.Nene, VishvanathSkilton, Robert A.Bishop, Richard P.[Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa]Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa

T cell responses play an important role in immunity to parasites and other microbial agents of infectious diseases, therefore a number of T cell-directed vaccines are in development. Computer-driven algorithms that facilitate the discovery of T cell epitopes from protein and genome sequences are ...


Groot, A.S.Nene, VishvanathHegde, N.R.Srikumaran, S.Rayner , J.Martin, W.[T cell epitope identification for bovine vaccines: An epitope mapping method for BoLA A-11]T cell epitope identification for bovine vaccines: An epitope mapping method for BoLA A-11
Bishop, Richard P.Sohanpal, B.K.Kariuki, D.Young, A.S.Nene, VishvanathBaylis, H.Allsopp, B.A.Spooner, P.R.Dolan, T.T.Morzaria, S.P.[Detection of a carrier state in Theileria parva infected cattle using the polymerase chain reaction]Detection of a carrier state in Theileria parva infected cattle using the polymerase chain reaction

A lambda gtll cDNA library was constructed using mRNA isolated from Theileria parva-infected bovine lymphocytes. Sequencing of random clones of this library resulted in the identification of a cDNA encoding bovine interleukin-16 (IL-16). The cDNA has an open reading frame of 1134 bp, and a 3? unt...


Mertens, B.Bishop, Richard P.Taracha, E.A.Morzaria, S.P.Nene, VishvanathSavadye, D.[Cloning, sequence and mRNA expression of bovine interleukin-16]Cloning, sequence and mRNA expression of bovine interleukin-16

Globally, malaria remains one of the most important vector-borne diseases despite the extensive use of vector control, including indoor residual spraying (IRS) and insecticide-treated nets (ITNs). These control methods target endophagic vectors, whereas some malaria vectors, such as Anopheles ara...


Poché, R.M.Githaka, Naftaly W.Gool, F. vanKading, R.C.Hartman, D.A.Polyakova, L.Abworo, E.O.Nene, VishvanathLozano-Fuentes, Saul[Preliminary efficacy investigations of oral fipronil against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions]Preliminary efficacy investigations of oral fipronil against Anopheles arabiensis when administered to Zebu cattle (Bos indicus) under field conditions

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