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Theileria parva, a tick-transmitted protozoan parasite related to Plasmodium spp., causes the disease East Coast fever, an acute and usually fatal lymphoproliferative disorder of cattle in Africa. Previous studies using sera from cattle that have survived infection identified a polymorphic immuno...


Toye, Philip G.Metzelaar, M.J.Wijngaard, P.L.J.Nene, VishvanathIams, K.P.Roose, J.Nyanjui, J.K.Gobright, E.I.Musoke, A.J.Clevers, H.C.[Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva]Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva

Ixodid ticks manipulate mammalian host pathways by secreting molecules from salivary glands. Novel cDNAs containing functional secretion signals were isolated from ixodid tick salivary glands using a signal sequence trap. Only 15/61 Rhipicephalus appendiculatus and 1/7 Amblyomma variegatum cDNAs ...


Lambson, B.Nene, VishvanathObura, M.Shah, TushaarPandit, P.Ole-MoiYoi, O.K.Delroux, K.Welburn, S.C.Skilton, Robert A.Villiers, Etienne P. deBishop, Richard P.[Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells]Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells

Several biochemical properties of a variant surface glycoprotein (VSG) from the parasite Trypanosoma (Duttonella) vivax have been determined. ILDat 2.1 VSG is approximately 40 kDa in size making this the smallest trypanosome VSG described to date. The glycolipid anchor of ILDat 2.1 VSG is resista...


Gardiner, Peter R.Nene, VishvanathBarry, M.M.Thatthi, R.Burleigh, B.Clarke, M.W.[Characterization of a small variable surface glycoprotein from Trypanosoma vivax]Characterization of a small variable surface glycoprotein from Trypanosoma vivax
Nene, VishvanathIams, K.P.Gobright, E.I.Musoke, A.J.[Characterisation of the gene encoding a candidate vaccine antigen of Theileria parva sporozoites]Characterisation of the gene encoding a candidate vaccine antigen of Theileria parva sporozoites

Hayashida, K.Hara, Y.Abe, T.Yamasaki, C.Toyoda, A.Kosuge, T.Suzuki, Y.Sato, Y.Kawashima, S.Katayama, T.Wakaguri, H.Inoue, N.Homma, K.Tada-Umezaki, M.Yagi, Y.Fujii, Y.Habara, T.Kanehisa, M.Watanabe, H.Ito, K.Gojobori, T.Sugawara, H.Imanishi, T.Weir, W.Gardner, M.Pain, A.Shiels, B.Hattori, M.Nene, VishvanathSugimoto, C.[Comparative genome analysis of three eukaryotic parasites with differing abilities to transform leukocytes reveals key mediators of Theileria-induced leukocyte transformation]Comparative genome analysis of three eukaryotic parasites with differing abilities to transform leukocytes reveals key mediators of Theileria-induced leukocyte transformation

Because the function of signal sequences has been conserved during evolution it has been possible to develop both bioinformatics resources to identify them and techniques to clone genes that encode secretary proteins. The latter entail insertion of heterologous signals upstream of signal peptide ...


Nene, VishvanathBishop, Richard P.[Trapping parasite secretory proteins in baker's yeast]Trapping parasite secretory proteins in baker's yeast

Previous data showed that six out of a group of nine cattle inoculated with NS1-p67, a recombinant form of a 67-KDa Theileria parva sporozoite surface protein, were immune to East Coast fever. This bacterialy expressed antigen encoded all 709 amino acid residues of p67 fused to the C-terminal end...


Nene, VishvanathInumaru, S.McKeever, Declan J.Morzaria, S.P.Shaw, M.Musoke, A.J.[Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle]Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle

Seago, J.Pérez, E.Harmsen, M.Lyons, N.Nene, VishvanathDekker, A.Charleston, B.[Improving quality assurance along the FMD vaccine production and supply chain]Improving quality assurance along the FMD vaccine production and supply chain

Completion of the Babesia bovis (T2Bo strain) genome provides detailed data concerning the predicted proteome of this parasite, and allows for a bioinformatics approach to gene discovery. Comparative genomics of the hemoprotozoan parasites B. bovis and Theileria parva revealed a highly conserved ...


Freeman, J.M.Kappmeyer, L.S.Ueti, M.W.McElwain, T.F.Baszler, T.V.Echaide, I.Nene, VishvanathKnowles, Donald P.[A Babesia bovis gene syntenic to Theileria parva p67 is expressed in blood and tick stage parasites]A Babesia bovis gene syntenic to Theileria parva p67 is expressed in blood and tick stage parasites

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