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Nyagwange, JamesAwino, EliasTijhaar, EdwinSvitek, NicholasPelle, RogerNene, Vishvanath[Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever]Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever

Theileria parva is a tick-transmitted intracellular protozoan parasite that causes East Coast fever, a fatal bovine lymphoproliferative disease. The molecular mechanisms that underlie host cell transformation by T. parva schizonts have been studied extensively, and it is known that the transcript...


Kyoko, H.Masakazu, H.Ryo, N.Yoshimasa, T.Jung-Yeon, K.Noboru, I.Nene, VishvanathChihiro, S.[A schizont-derived protein, TpSCOP, is involved in the activation of NF-κB in Theileria parva-infected lymphocytes]A schizont-derived protein, TpSCOP, is involved in the activation of NF-κB in Theileria parva-infected lymphocytes

Ixodid ticks manipulate mammalian host pathways by secreting molecules from salivary glands. Novel cDNAs containing functional secretion signals were isolated from ixodid tick salivary glands using a signal sequence trap. Only 15/61 Rhipicephalus appendiculatus and 1/7 Amblyomma variegatum cDNAs ...


Lambson, B.Nene, VishvanathObura, M.Shah, TushaarPandit, P.Ole-MoiYoi, O.K.Delroux, K.Welburn, S.C.Skilton, Robert A.Villiers, Etienne P. deBishop, Richard P.[Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells]Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells

The ticks Rhipicephalus appendiculatus and Rhipicephalus sanguineus are the main vectors of Theileria parva and Babesia spp. in cattle and dogs, respectively. Due to their impact in veterinary care and industry, improved methods against R. appendiculatus and R. sanguineus parasitism are under dev...


Sabadin, G.A.Parizi, L.F.Kiio, I.Xavier, M.A.Silva Matos, R. daCamargo-Mathias, M.I.Githaka, Naftaly W.Nene, VishvanathSilva Vaz, I. da[Effect of recombinant glutathione S-transferase as vaccine antigen against Rhipicephalus appendiculatus and Rhipicephalus sanguineus infestation]Effect of recombinant glutathione S-transferase as vaccine antigen against Rhipicephalus appendiculatus and Rhipicephalus sanguineus infestation

Molecules located on cell surfaces and those that are secreted from the cell frequently play a critical role in cell biology by mediating interaction with the external environment. These types of parasite molecules often constitute targets for protective host immune responses and are thus of addi...


Musembi, S.Janoo, R.T.K.Sohanpal, B.K.Ochanda, H.Ole-MoiYoi, O.K.Bishop, Richard P.Nene, Vishvanath[Screening for Theileria parva secretory gene products by functional analysis in Saccharomyces cerevisiae]Screening for Theileria parva secretory gene products by functional analysis in Saccharomyces cerevisiae

Bovine theileriosis caused by Theileria parva continues to be a major economic problem in many parts of Eastern, Southern, and Central Africa. Due to the unsustainable nature or the present control method-using toxic acaricides to kill ticks - alternative control methods are being sought. Live va...


Morzaria, S.P.Nene, VishvanathBishop, Richard P.Musoke, A.J.[Vaccines against Theileria parva]Vaccines against Theileria parva

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