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Silva Pereira, S.Casas-Sánchez, A.Haines, L.R.Ogugo, Moses W.Kihara, AbsolomonSanders, M.Kemp, Stephen J.Acosta-Serrano, Á.Noyes, H.Berriman, M.Jackson, A.P.[Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs]Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs

This study aimed to provide the foundation for an integrative approach to the identification of the mechanisms underlying the response to infection with Trypanosoma congolense, and to identify pathways that have previously been overlooked. We undertook a large-scale gene expression analysis study...


Kierstein, S.Noyes, H.Naessens, JanNakamura, Y.Pritchard, J.Gibson, John P.Kemp, Stephen J.Brass, A.[Gene expression profiling in a mouse model for African trypanosomiasis]Gene expression profiling in a mouse model for African trypanosomiasis

A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens...


Behnke, J.M.Menge, D.M.Nagda, S.M.Noyes, H.Iraqi, F.A.Kemp, Stephen J.Mugambi, R.J.M.Baker, R.L.Wakelin, D.Gibson, John P.[Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice]Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

Mammals are able to rapidly produce red blood cells in response to stress. The molecular pathways used in this process are important in understanding responses to anaemia in multiple biological settings. Here we characterise the novel gene Claudin 13 (Cldn13), a member of the Claudin family of ti...


Thompson, P.D.Tipney, H.Brass, A.Noyes, H.Kemp, Stephen J.[Claudin 13, a member of the claudin family regulated in mouse stress Induced erythropoiesis]Claudin 13, a member of the claudin family regulated in mouse stress Induced erythropoiesis

It is increasingly common to combine Microarray and Quantitative Trait Loci data to aid the search for candidate genes responsible for phenotypic variation. Workflows provide a means of systematically processing these large datasets and also represent a framework for the re-use and the explicit d...


Fisher, P.Hedeler, C.Wolstencroft, K.Hulme, H.Noyes, H.Kemp, Stephen J.Stevens, R.Brass, A.[A systematic strategy for large-scale analysis of genotype-phenotype correlations: identification of candidate genes involved in African trypanosomiasis]A systematic strategy for large-scale analysis of genotype-phenotype correlations: identification of candidate genes involved in African trypanosomiasis

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