The protozoan parasite Theileria parva infects and transforms bovine lymphocytes, giving rise to a fatal lympho-proliferative condition known as East Coast fever. Although immune cattle mount strong cytolytic T. lymphocyte responses to the parasite, naive animals appear unable to respond and deve...
McKeever, Declan J.
,
Nyanjui, J.K.
,
Ballingall, K.T.
,
[In vitro infection with Theileria parva is associated with IL10 expression in all bovine lymphocyte lineages]
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In vitro infection with Theileria parva is associated with IL10 expression in all bovine lymphocyte lineages
There is growing evidence that immunity of cattle to Cowdria ruminantium infection is mediated by T lymphocytes. C. ruminantium antigens that stimulate these responses are therefore of considerable importance to the development of a sub-unit vaccine against the disease. We have examined T cell re...
Mwangi, D.M.
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McKeever, Declan J.
,
Nyanjui, J.K.
,
Barbet, A.F.
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Mahan, S.M.
,
[Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent]
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Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent
Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymor...
Graham, S.P.
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Saya, R.
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Awino, Elias
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Ngugi, D.
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Nyanjui, J.K.
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Hecker, R.
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Taracha, E.L.N.
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Nene, Vishvanath
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[Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva]
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Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva
Peripheral blood mononuclear cells (PBMC) from immune cattle proliferate in the presence of autologous Cowdria ruminantium-infected endothelial cells and monocytes. Endothelial cells required treatment with T-cell growth factors to induce class II major histocompatibility complex expression prior...
Mwangi, D.M.
,
Mahan, S.M.
,
Nyanjui, J.K.
,
Taracha, E.L.N.
,
McKeever, Declan J.
,
[Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes]
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Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes
Heartwater (cowdriosis) is an infectious disease of domestic ruminants in Africa and the Carribean and is caused by a tick-borne intracellular rickettsial agent, Cowdria ruminantium. There is growing evidence that immunity of cattle to the disease is medicated by T. lymphocytes. Antigens that sti...
Mwangi, D.M.
,
McKeever, Declan J.
,
Nyanjui, J.K.
,
Barbet, A.F.
,
Mahan, S.M.
,
[Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle]
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Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle