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The chicken lysozyme gene encodes a hydrolase that has a key role in defence, especially in ovo. This gene was resequenced in global chicken populations [red, grey, Ceylon and green jungle fowl (JF)] and related bird species. Networks, summary statistics and tests of neutrality indicate that alth...


Downing, T.O'Farrelly, C.O.Bhuiyan, A.K.F.H.Silva, P.Naqvi, A.N.Sanfo, R.Sow, R.S.Overseas Development InstituteHanotte, Olivier H.Bradley, D.G.[Variation in chicken populations may affect the enzymatic activity of lysozyme]Variation in chicken populations may affect the enzymatic activity of lysozyme

There have been significant evolutionary pressures on the chicken during both its speciation and its subsequent domestication by man. Infectious diseases are expected to have exerted strong selective pressures during these processes. Consequently, it is likely that genes associated with disease s...


Downing, T.Lynn, D.J.Connell, S.Lloyd, A.T.Bhuiyan, A.K.F.H.Silva, P.Naqvi, A.N.Sanfo, R.Sow, R.S.Overseas Development InstituteO'Farrelly, C.O.Hanotte, Olivier H.Bradley, D.G.[Contrasting evolution of diversity at two disease-associated chicken genes]Contrasting evolution of diversity at two disease-associated chicken genes

African animal trypanosomiasis (AAT) is endemic across Sub-Saharan African and is a major constraint to livestock production. The ability of certain cattle breeds to remain productive despite infection is known as trypanotolerance; however, the underlying immune mechanisms contributing to this tr...


Meade, K.G.O'Gorman, G.M.Hill, E.W.Narciandi, F.Agaba, MorrisKemp, Stephen J.O'Farrelly, C.O.MacHugh, D.E.[Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle]Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle

The comparative analysis of genome sequences emerging for several avian species with the fully sequenced chicken genome enables the genome-wide investigation of selective processes in functionally important chicken genes. In particular, because of pathogenic challenges it is expected that genes i...


Downing, T.Lynn, D.J.Connel, S.Lloyd, A.T.Bhuiyan, A.K.F.H.Silva, P.Naqvi, A.N.Sanfo, R.Sow, R.S.Overseas Development InstituteHanotte, Olivier H.O'Farrelly, C.O.Bradley, D.[Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus]Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus

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