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A cross-sectional study was conducted to determine the seroprevalence of Brucella spp. and Leptospira spp. and risk factors of exposure in cattle in three zones with varying land use types and wildlife–livestock interactions. Five villages were selected purposively; two in areas with intensive li...


Nthiwa, D.Alonso, SilviaOdongo, D.Kenya, E.Bett, Bernard K.[Zoonotic pathogen seroprevalence in cattle in a wildlife–livestock interface, Kenya]Zoonotic pathogen seroprevalence in cattle in a wildlife–livestock interface, Kenya

Vaccines based on recombinant Bm86 gut antigen from Boophilus microplus are a useful component of integrated control strategies against B. microplus infestations of cattle. The capacity of such vaccines to control heterologous infestations by two African tick species was investigated. The mean we...


Odongo, D.Kamau, L.Skilton, Robert A.Mwaura, S.Nitsch, C.Musoke, A.J.Taracha, E.A.Daubenberger, C.A.Bishop, Richard P.[Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus]Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus

Several tannin-tolerant bacteria were isolated from enrichment cultures of rumen microflora of bush duiker, giraffe, Grant's gazelle, sheep, and goat, and established in medium containing crude tannin extracts or tannic acid. The isolates were characterized by classical and molecular methods. The...


Odenyo, A.A.Bishop, Richard P.Asefa, G.Jamnadass, Ramni H.Odongo, D.Osuji, P.O.[Characterization of tannin-tolerant bacterial isolates from East African ruminants]Characterization of tannin-tolerant bacterial isolates from East African ruminants

Two recombinant vaccines against Theileria parva, based on a near full-length version of the sporozoite surface antigen p67 (p67635), or an 80 amino acid C-terminal section (p67C), were evaluated by exposure of immunized cattle to natural tick challenge in two sites at the Kenya Coast and one i...


Musoke, A.J.Rowlands, G.J.Nene, VishvanathNyanjui, J.Katende, J.Spooner, P.R.Mwaura, S.Odongo, D.Nkonge, C.Mbogo, S.Bishop, Richard P.Morzaria, S.P.[Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge]Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge

There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases. East Coast fever, caused by the protist Theileria parva, kills one million cattle each year in sub-Saharan Africa, ...


Norling, M.Bishop, Richard P.Pelle, RogerWeihong QiHenson, S.Drábek, E.F.Tretina, K.Odongo, D.Mwaura, S.Njoroge, T.Bongcam-Rudloff, E.Daubenberger, C.A.Silva, J.C.[The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence]The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence
Hassan, S.Skilton, R.A.Pelle, RogerOdongo, D.Bishop, Richard P.Ahmed, J.Seitzer, U.Bakheit, M.Hassan, S.M.El Hussein, A.M.[Assessment of the prevalence of Theileria lestoquardi in sheep from the Sudan using serological and molecular methods]Assessment of the prevalence of Theileria lestoquardi in sheep from the Sudan using serological and molecular methods

Sequences from a tannin-tolerant Selenomonas ruminantium isolate (EAT2) that hydrolyzes gallic acid were identified. Two exhibited identity to helicases with a wide phylogenetic distribution. PCR amplification by using primers from one helicase gene detected 2,000 to 5,000 EAT2 genome equivalents...


Bishop, Richard P.Obura, M.Odongo, D.Odenyo, A.A.[Specific PCR assay for a tannin-tolerant Selenomonas ruminantium isolate, derived from helicase coding sequences]Specific PCR assay for a tannin-tolerant Selenomonas ruminantium isolate, derived from helicase coding sequences

Protective immunity induced by the infective sporozoite stage of Theileria parva indicates a potential role for antibodies directed against conserved serologically reactive regions of the major sporozoite surface antigen p67 in vaccination to control the parasite. We have examined the allelic var...


Obara, I.Ulrike, S.Musoke, A.J.Spooner, P.R.Jabbar, A.Odongo, D.Kemp, Stephen J.Silva, J.C.Bishop, Richard P.[Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva]Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva

Commercial vaccines based on the tick gut protein Bm86 have been successful in controlling the one-host tick Rhipicephalus (Boophilus) microplus and provide heterologous protection against certain other non-target ixodid tick species. This cross protection, however, does not extend to the three-h...


Olds, Cassandra L.Mwaura, S.Crowder, D.Odongo, D.Oers, M.M. vanOwen, J.Bishop, Richard P.Daubenberger, C.A.[Immunization of cattle with Ra86 impedes Rhipicephalus appendiculatus nymphal-to-adult molting]Immunization of cattle with Ra86 impedes Rhipicephalus appendiculatus nymphal-to-adult molting
Lutta, H.O.Mather, A.Maina, T.W.Odongo, D.Ndiwa, Nicholas N.Wesonga, H.O.Naessens, Jan[Preliminary findings of lipoprotein B in detecting cattle chronically infected with contagious bovine pleuropneumonia]Preliminary findings of lipoprotein B in detecting cattle chronically infected with contagious bovine pleuropneumonia

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