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Several studies have shown that a single exposure to stress may improve or impair learning and memory processes, depending on the timing in which the stress event occurs with relation to the acquisition phase. However, to date there is no information about the molecular changes that occur at the ...


Aguayo, F.I.Tejos-Bravo, M.Díaz-Véliz, G.Pacheco, A.García-Rojo, G.Corrales, W.Olave, F.A.Aliaga, E.Ulloa, J.L.Avalos, A.M.Román-Albasini, L.Rojas, P.S.Fiedler, J.L.[Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study]Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study

Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared the effect of repeated stress on the expression of α-amino-3-hydroxy-5-meth...


Pacheco, A.Aguayo, F.I.Aliaga, E.Muñoz, M.García-Rojo, G.Olave, F.A.Parra-Fiedler, N.A.García-Pérez, A.Tejos-Bravo, M.Rojas, P.S.Parra, C.S.Fiedler, J.L.[Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats]Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats

Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, a high-glucose hyperosmotic (HGH) solution is administered into the peritone...


Simon, F.Tapia, P.Armisen, R.Echeverria, C.Gatica, S.Vallejos, A.Pacheco, A.Sanhueza, M.E.Alvo, M.Segovia, E.Torres, R.[Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways]Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways

Studies conducted in rodents subjected to chronic stress and some observations in humans after psychosocial stress, have allowed to establish a link between stress and the susceptibility to many complex diseases, including mood disorders. The studies in rodents have revealed that chronic exposure...


Muñoz-Llanos, M.García-Pérez, M.A.Xu, X.Tejos-Bravo, M.Vidal, E.A.Moyano, T.C.Gutiérrez, R.A.Aguayo, F.I.Pacheco, A.García-Rojo, G.Aliaga, E.Rojas, P.S.Cidlowski, J.A.[MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology]MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology

Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply modifications in dendritic cytoskeleton. Rho GTPases are regulators of ac...


García-Rojo, G.Fresno, C.Vilches, N.Díaz-Véliz, G.Mora, S.Aguayo, F.Pacheco, A.Parra-Fiedler, N.Parra, C.S.Rojas, P.S.Tejos, M.Aliaga, E.Fiedler, J.L.[The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus]The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus

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