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Murphy, N.B.Pelle, Roger[The use of arbitrary primers and the RADES method for the rapid identification of developmentally regulated genes in trypanosomes]The use of arbitrary primers and the RADES method for the rapid identification of developmentally regulated genes in trypanosomes
Pelle, RogerMcOdimba, F.A.Chuma, FrancisWasawo, D.Pearson, T.W.Murphy, N.B.[The African trypanosome cyclophilin A homologue contains unusual conserved central and N-terminal domains and is developmentally regulated]The African trypanosome cyclophilin A homologue contains unusual conserved central and N-terminal domains and is developmentally regulated
Sitt, T.Pelle, RogerWeir, W.Steinaa, LucillaMorrison, W. IvanToye, Philip G.[Genotypic and antigenic diversity of Theileria parva in buffalo and buffalo-associated cattle]Genotypic and antigenic diversity of Theileria parva in buffalo and buffalo-associated cattle

Although immunodominance of CD8+ T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear. In previous studies we have observed that CD8+ T-cell responses to Theileria parva exhibit different patterns of parasit...


MacHugh, Niall D.Connelley, T.Graham, S.P.Pelle, RogerFormisano, P.Taracha, E.L.N.Ellis, S.A.McKeever, Declan J.Burrells, A.Morrison, W. Ivan[CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity]CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity
Pelle, Roger[The use of electrophoretic profile of RNA to differentiate Trypanosoma brucei from T. congolense]The use of electrophoretic profile of RNA to differentiate Trypanosoma brucei from T. congolense

East Coast fever (ECF) is a highly fatal lymphoproliferative disease of cattle caused by Theileria parva, a tick-borne intracellular apicomplexan parasite. Parasite antigens that are targets of protective cytotoxic T lymphocyte (CTL) responses are required to formulate a sub-unit vaccine against ...


Akoolo, L.Pelle, RogerSaya, R.Awino, EliasNyanjui, J.Taracha, E.L.N.Kanyari, P.Mwangi, D.M.Graham, S.P.[Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle]Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated through the destruction of parasite infected lymphocytes by MHC class I restricted CD8+ CTL. Six parasite proteins targeted by CTL from T. parva immune cattle have been identified and raised...


Graham, S.P.Pelle, RogerVilliers, Etienne P. deYamage, M.Mwangi, D.M.Honda, Y.Ellis, S.A.MacHugh, Niall D.Morrison, W. IvanTaracha, E.L.N.[Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva]Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva

Theileria parva antigens recognized by cytotoxic T lymphocytes (CTLs) are prime vaccine candidates against East Coast Fever in cattle. A strategy for enhancing induction of parasite-specific T cell responses by increasing recruitment and activation of dendritic cells (DCs) at the immunization sit...


Mwangi, D.M.Honda, Y.Graham, S.P.Pelle, RogerTaracha, E.L.N.Gachanja, J.Nyanjui, J.K.Bray, J.Palmer, G.H.Brown, W.C.Mwangi, W.[Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses]Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses
Cho-Ngwa, F.Assam-Assam, J.P.Ane-Anyangwe, I.Skilton, Robert A.Pelle, RogerKitavi, M.Nzuki, I.Nyonka, J.Tedom, J.C.Beng, V.P.Akoachere, Jane-FrancisNjie, M.Titanji, V.P.K.[Molecular and phenotypic characterisation of mycobacterium tuberculosis complex]Molecular and phenotypic characterisation of mycobacterium tuberculosis complex

N-Ribohydrolases, including the inosine-adenosine-guanosine-preferring (IAG) nucleoside hydrolase, have been proposed to be involved in the nucleoside salvage pathway of protozoan parasites and may consitute rational therapeutic targets for the treatment of these diseases. Reported is the complet...


Pelle, RogerSchramm, V.L.Parkin, D.W.[Molecular cloning and expression of a purine-specific N-ribohydrolase from Trypanosoma brucei brucei. Sequence expression and molecular analysis]Molecular cloning and expression of a purine-specific N-ribohydrolase from Trypanosoma brucei brucei. Sequence expression and molecular analysis

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