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Background Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod vector, which involves an obligate sexual cy...


Henson, S.Bishop, Richard P.Morzaria, S.P.Spooner, P.R.Pelle, RogerPoveda, L.Ebeling, M.Kung, E.Certa, U.Daubenberger, C.A.Weihong Qi[High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing]High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing
Sitt, T.Pelle, RogerChepkwony, M.C.Morrison, W. IvanToye, Philip G.[Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines]Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines
Nyagwange, JamesAwino, EliasTijhaar, EdwinSvitek, NicholasPelle, RogerNene, Vishvanath[Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever]Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever

Theileria parva is a parasitic protozoan that causes East Coast fever (ECF), an economically important disease of cattle in eastern, central and southern Africa. In South Sudan, ECF is considered a major constraint for livestock development in regions where the disease is endemic. To obtain insig...


Salih, Diaeldin A.Mwacharo, Joram M.Pelle, RogerNjahira, Moses N.Odongo, David O.Mbole-Kariuki, Mary N.Marcellino, Wani L.Malak, Agol K.Kiara, Henry K.El Hussein, A.R.M.Bishop, Richard P.Skilton, Robert A.[Genetic diversity and population structure of Theileria parva in South Sudan]Genetic diversity and population structure of Theileria parva in South Sudan
Tonui, TrizaCorredor-Moreno, PilarKanduma, E.Njuguna, Joyce N.Njahira, Moses N.Nyanjom, S.G.Silva, J.C.Djikeng, AppolinairePelle, Roger[Transcriptomics reveal potential vaccine antigens and a drastic increase of upregulated genes during Theileria parva development from arthropod to bovine infective stages]Transcriptomics reveal potential vaccine antigens and a drastic increase of upregulated genes during Theileria parva development from arthropod to bovine infective stages

An infection and treatment protocol involving infection with a mixture of three parasite isolates and simultaneous treatment with oxytetracycline is currently used to vaccinate cattle against Theileria parva. While vaccination results in high levels of protection in some regions, little or no pro...


Hemmink, J.D.Sitt, T.Pelle, RogerKlerk-Lorist, L.M. deShiels, B.Toye, Philip G.Morrison, W. IvanWeir, W.[Ancient diversity and geographical sub-structuring in African buffalo Theileria parva populations revealed through metagenetic analysis of antigen-encoding loci]Ancient diversity and geographical sub-structuring in African buffalo Theileria parva populations revealed through metagenetic analysis of antigen-encoding loci

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