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Recent studies suggest that peptidyl-prolyl isomerases of the cyclophilin family, that access the secretory pathway, can be involved in the interaction of parasitic protozoa with mammalian host cells. The amino acid sequence of a cDNA encoding a cyclophilin family member of the intracellular pro...


Ebel, T.Pelle, RogerJanoo, R.T.K.Lipp, J.Bishop, Richard P.[A membrane-anchored Theileria parva cyclophilin with a non-cleaved amino-terminal signal peptide for entry into the endoplasmic reticulum]A membrane-anchored Theileria parva cyclophilin with a non-cleaved amino-terminal signal peptide for entry into the endoplasmic reticulum
Sitt, T.Pelle, RogerWeir, W.Steinaa, LucillaShiels, B.Morrison, W. IvanToye, Philip G.[Theileria parva: Genotypic and antigenic diversity in buffalo and buffalo-associated cattle]Theileria parva: Genotypic and antigenic diversity in buffalo and buffalo-associated cattle
Pelle, RogerMurphy, N.B.[In vivo UV cross-linking hybridization, a powerful technique for isolating RNA binding proteins: Application to trypanosome mini-exon derived RNA]In vivo UV cross-linking hybridization, a powerful technique for isolating RNA binding proteins: Application to trypanosome mini-exon derived RNA

The purine salvage pathway of parasitic protozoa is currently considered as a target for drug development because these organisms cannot synthesize purines de novo. Insight into the structure and mechanism of the involved enzymes can aid in the development of potent inhibitors, leading to new cur...


Versees, W.Decanniere, K.Pelle, RogerDepoorter, J.Brosens, E.Parkin, D.W.Steyaert, J.[Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax]Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax

Cyclophilin A from the bovine parasite Trypanosoma brucei brucei has been cloned, expressed in Escherichia coli, purified and crystallized in the presence of cyclosporin A using ammonium sulfate as a precipitant. The crystals belong to the orthorhombic crystal system with unit-cell dimensions of ...


Dao-Thi, M.H.Transue, T.R.Pelle, RogerMurphy, N.B.Poortmans, F.Steyaert, J.[Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei]Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei
Mwambene, Pius L.Kyallo, MartinaMachuka, EuniceGithae, DedanPelle, Roger[Genetic diversity of 10 indigenous chicken ecotypes from Southern Highlands of Tanzania based on Major Histocompatibility Complex-linked microsatellite LEI0258 marker typing]Genetic diversity of 10 indigenous chicken ecotypes from Southern Highlands of Tanzania based on Major Histocompatibility Complex-linked microsatellite LEI0258 marker typing
Mpenda, F.N.Tiambo, Christian K.Kyallo, MartinaPelle, RogerLyantagaye, S.L.Buza, J.[Polymorphisms of the chicken Mx gene promoter and association with chicken embryos’ susceptibility to virulent Newcastle disease virus challenge]Polymorphisms of the chicken Mx gene promoter and association with chicken embryos’ susceptibility to virulent Newcastle disease virus challenge

There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases. East Coast fever, caused by the protist Theileria parva, kills one million cattle each year in sub-Saharan Africa, ...


Norling, M.Bishop, Richard P.Pelle, RogerWeihong QiHenson, S.Drábek, E.F.Tretina, K.Odongo, D.Mwaura, S.Njoroge, T.Bongcam-Rudloff, E.Daubenberger, C.A.Silva, J.C.[The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence]The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence

Peptidases of parasitic protozoans are emerging as novel virulence factors and therapeutic targets in parasitic infections. A trypanosome-derived aminopeptidase that exclusively hydrolysed substrates with Glp (pyroglutamic acid) in P1 was purified 9248-fold from the plasma of rats infected with T...


Morty, R.E.Bulau, P.Pelle, RogerWilki, S.Abe, K.[Pyroglutamyl peptidase type I from Trypanosoma brucei: A new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts]Pyroglutamyl peptidase type I from Trypanosoma brucei: A new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts

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