A Trypanosoma brucei brucei DNA repeat sequence termed NlaIII repeat (NR) was originally isolated from a multidrug-resistant field isolate CP547 [Jamnadass, R., 1995. Identification and characterisation of an extrachromosomal element from a multidrug-resistant isolate of T. brucei brucei, Ph.D. t...
Jamnadass, Ramni H.
,
Pelle, Roger
,
Pandit, P.
,
Ricard, B.
,
Murphy, N.B.
,
[Trypanosoma brucei: Composition, organisation, plasticity, and differential transcription of NlaIII repeat elements in drug-resistant and sensitive isolates]
,
Trypanosoma brucei: Composition, organisation, plasticity, and differential transcription of NlaIII repeat elements in drug-resistant and sensitive isolates
Pelle, Roger
,
[The use of electrophoretic profile of RNA to differentiate Trypanosoma brucei from T. congolense]
,
The use of electrophoretic profile of RNA to differentiate Trypanosoma brucei from T. congolense
N-Ribohydrolases, including the inosine-adenosine-guanosine-preferring (IAG) nucleoside hydrolase, have been proposed to be involved in the nucleoside salvage pathway of protozoan parasites and may consitute rational therapeutic targets for the treatment of these diseases. Reported is the complet...
Pelle, Roger
,
Schramm, V.L.
,
Parkin, D.W.
,
[Molecular cloning and expression of a purine-specific N-ribohydrolase from Trypanosoma brucei brucei. Sequence expression and molecular analysis]
,
Molecular cloning and expression of a purine-specific N-ribohydrolase from Trypanosoma brucei brucei. Sequence expression and molecular analysis
Cyclophilin A from the bovine parasite Trypanosoma brucei brucei has been cloned, expressed in Escherichia coli, purified and crystallized in the presence of cyclosporin A using ammonium sulfate as a precipitant. The crystals belong to the orthorhombic crystal system with unit-cell dimensions of ...
Dao-Thi, M.H.
,
Transue, T.R.
,
Pelle, Roger
,
Murphy, N.B.
,
Poortmans, F.
,
Steyaert, J.
,
[Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei]
,
Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei
Peptidases of parasitic protozoans are emerging as novel virulence factors and therapeutic targets in parasitic infections. A trypanosome-derived aminopeptidase that exclusively hydrolysed substrates with Glp (pyroglutamic acid) in P1 was purified 9248-fold from the plasma of rats infected with T...
Morty, R.E.
,
Bulau, P.
,
Pelle, Roger
,
Wilki, S.
,
Abe, K.
,
[Pyroglutamyl peptidase type I from Trypanosoma brucei: A new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts]
,
Pyroglutamyl peptidase type I from Trypanosoma brucei: A new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts