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The expression and characterization of a recombinant antigen termed Ov-47 are described. Ov-47 was identified and isolated from a lambda gt-11 eDNA expression library derived from adult female Onclrucercu volvukrs mRNA using rabbit antiserum raised against the surface proteins of O. vulvulcw fema...


Ghoyomu, S.M.Souopgui, J.Pelle, RogerTitanji, V.P.K.[Expression and characterization of Ov-47, a dominant antigen of Onchocerca volvulus]Expression and characterization of Ov-47, a dominant antigen of Onchocerca volvulus
Masake, R.A.Nantulya, V.M.Pelle, RogerMakau, J.M.Gathuo, H.K.W.Ole-MoiYoi, O.K.[A species-specific antigen of Trypanosoma (Duttonella) vivax detectable in the course of infection is encoded by a differentially-expressed tandemly reiterated gene]A species-specific antigen of Trypanosoma (Duttonella) vivax detectable in the course of infection is encoded by a differentially-expressed tandemly reiterated gene

Objective: To determine the role of an immunodominant antigen OvPG-1 in human onchocerciasis. Design: Cross-sectional study of subjects living in three onchocerciasis endemic areas. Setting: Mbonge and Tubah divisions of Western Cameroon and in Esmeralda Province of Ecuador. Subjects: There were ...


Amambua, A.N.Tachu, J.B.Ghogomu, S.M.Pelle, RogerTitanji, V.P.K.[Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus]Characterisation of a heparan sulfate proteoglycan homologue OVPG-1 from Onchocerca volvulus

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated through the destruction of parasite infected lymphocytes by MHC class I restricted CD8+ CTL. Six parasite proteins targeted by CTL from T. parva immune cattle have been identified and raised...


Graham, S.P.Pelle, RogerVilliers, Etienne P. deYamage, M.Mwangi, D.M.Honda, Y.Ellis, S.A.MacHugh, Niall D.Morrison, W. IvanTaracha, E.L.N.[Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva]Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva

The development of a sterilizing and cost-effective vaccine against malaria remains a major problem despite recent advances. In this study, it is demonstrated that two antigens of P. falciparum UB05, UB09 and their chimera UB05-09 can serve as protective immunity markers by eliciting higher T-cel...


Dinga, J.N.Njimoh, D.L.Kiawa, B.Djikeng, AppolinaireNyasa, R.B.Nkuo-Akenji, T.Pelle, RogerTitanji, V.P.K.[Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria]Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated by CD8 T cells. Six antigens targeted by CD8 T cells from T. parva-immune cattle of different major histocompatibility complex (MHC) genotypes have been identified, raising the prospect of d...


Graham, S.P.Pelle, RogerYamage, M.Mwangi, D.M.Honda, Y.Mwakubambanya, R.S.Villiers, Etienne P. deAbuya, E.Awino, EliasGachanja, J.Mbwika, F.Muthiani, A.M.Muriuki, C.Nyanjui, J.K.[Characterization of the fine specificity of Bovine CD8 T-Cell responses to defined antigens from the protozoan parasite Theileria parva]Characterization of the fine specificity of Bovine CD8 T-Cell responses to defined antigens from the protozoan parasite Theileria parva

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