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Journal Article 1993

Autor: Gray, M.A. Peregrine, A.S.

The sensitivity of seven populations of T. congolense to the salts of three trypanocides, diminazene, isometamidium and homidium, were determined in vitro using in vitro-derived metacyclic trypanosomes. The trypanosomes were incubated at 35 degree centigrade for 48 hours with various drug concent...

Enlace original: https://cgspace.cgiar.org/handle/10568/27979

Investigación en Agricultura
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Gray, M.A. ,  Peregrine, A.S. ,  [An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes] ,  An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes
Journal Article 2001

Autor: Eisler, M.C. Brandt, J. Bauer, B. Clausen, P.H. Delespaux, V. Holmes, P.H. Ilemobade, A. Machila, N. Mbwambo, H. McDermott, John J. Mehlitz, D. Murilla, G. Ndung'u, J.M. Peregrine, A.S. Sidibe, I. Sinyangwe, L. Geerts, S.

Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...

Enlace original: https://cgspace.cgiar.org/handle/10568/33255

Investigación en Agricultura
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Eisler, M.C. ,  Brandt, J. ,  Bauer, B. ,  Clausen, P.H. ,  Delespaux, V. ,  Holmes, P.H. ,  Ilemobade, A. ,  Machila, N. ,  Mbwambo, H. ,  McDermott, John J. ,  Mehlitz, D. ,  Murilla, G. ,  Ndung'u, J.M. ,  Peregrine, A.S. ,  Sidibe, I. ,  Sinyangwe, L. ,  Geerts, S. ,  [Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle] ,  Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle
Journal Article 1997

Autor: Wilkes, J.M. Mulugeta, W. Wells, C. Peregrine, A.S.

Bloodstream forms of four populations of the livestock pathogen Trypanosoma congolense, isolated from different natural infections, have been shown to exhibit a wide range of sensitivities to the trypanocide isometamidium chloride (Samorin). In mice the 50 percent curative doses (CD 50) for Samor...

Enlace original: https://cgspace.cgiar.org/handle/10568/30092

Investigación en Agricultura
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Wilkes, J.M. ,  Mulugeta, W. ,  Wells, C. ,  Peregrine, A.S. ,  [Modulation of mitochondrial electrical potential: A candidate mechanism for drug resistance in African trypanosomes] ,  Modulation of mitochondrial electrical potential: A candidate mechanism for drug resistance in African trypanosomes
Conference Paper 2000

Autor: Peregrine, A.S. Wells, C.W. Wilkes, J.M.

Characterising the drug susceptibility of trypanosomes that are pathogenic for domestic livestock has for many years been carried out either in vivo, using large or small animals, or by using various in vitro cultivation methodologies (Peregrine, 1994). Thus, adaptation to, and multiplication of ...

Enlace original: https://cgspace.cgiar.org/handle/10568/50845

Investigación en Agricultura
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Peregrine, A.S. ,  Wells, C.W. ,  Wilkes, J.M. ,  [Methods for detection of drug resistance in trypanosomes - new developments?] ,  Methods for detection of drug resistance in trypanosomes - new developments?
Conference Paper 2000

Autor: McDermott, John J. Coleman, P.G. Eisler, M.C. Peregrine, A.S.

Tsetse-transmitted trypanosomosis affects cattle production over approximately 10 million km2 of Africa. In these areas, trypanocidal drugs, both prophylactic and curative, are the most widely used methods of trypanosomosis control. However, resistance of trypanosomes to the 3 trypanocidal drugs ...

Enlace original: https://cgspace.cgiar.org/handle/10568/51156

Investigación en Agricultura
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McDermott, John J. ,  Coleman, P.G. ,  Eisler, M.C. ,  Peregrine, A.S. ,  [The effects of resistance to trypanocidal drugs on trypanosome transmission] ,  The effects of resistance to trypanocidal drugs on trypanosome transmission
Conference Paper 2000

Autor: Eisler, M.C. Ndung'u, J.M. Murilla, G. Mdachi, R.M. Mbwambo, H. Sinyangwe, L. Machila, N. Delespaux, V. Geerts, S. Brandt, J. Peregrine, A.S. McDermott, John J. Holmes, P.H.

The extent and significance of trypanocidal drug resistance was investigated in priority areas of three East and Southern African Countries under a project. The project was built on the results of two previous projects. Existing methods currently available for the demonstration of drug-resistance...

Enlace original: https://cgspace.cgiar.org/handle/10568/50192

Investigación en Agricultura
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Eisler, M.C. ,  Ndung'u, J.M. ,  Murilla, G. ,  Mdachi, R.M. ,  Mbwambo, H. ,  Sinyangwe, L. ,  Machila, N. ,  Delespaux, V. ,  Geerts, S. ,  Brandt, J. ,  Peregrine, A.S. ,  McDermott, John J. ,  Holmes, P.H. ,  [Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa] ,  Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa
Conference Paper 1995

Autor: Coulibaly, L. Hecker, P.A. Krebs, H.A. Rowlands, G.J. D'Ieteren, G.D.M. Leak, S.G.A. Peregrine, A.S. Nagda, S.M.

Twelve traditional herds of cattle in the area of Boundiali, northern Cote d'Ivoire, were examined monthly from 1990 to 1992 for the presence of trypanosomes. The herds were randomised into 3 treatment groups, cattle in 4 herds received diminazene aceturate at 3.5 or 7 mg/kg body weight (b.w.) wh...

Enlace original: https://cgspace.cgiar.org/handle/10568/50524

Investigación en Agricultura
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Coulibaly, L. ,  Hecker, P.A. ,  Krebs, H.A. ,  Rowlands, G.J. ,  D'Ieteren, G.D.M. ,  Leak, S.G.A. ,  Peregrine, A.S. ,  Nagda, S.M. ,  [Failure of trypanocidal drugs to cure trypanosome infections in cattle in Boundiali District, northern Cote d'Ivoire] ,  Failure of trypanocidal drugs to cure trypanosome infections in cattle in Boundiali District, northern Cote d'Ivoire

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