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The relationship between serum concentrations of the prophylactic trypanocidal drug isometamidium chloride and protection against tsetse challenge with two populations of Trypanosoma congolense was investigated in Boran (Bos indicus) cattle, using an isometamidium-ELISA. Isometamidium chloride (S...


Eisler, M.C.Gault, E.A.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense]Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense
Peregrine, A.S.Moloo, S.K.Whitelaw, D.D.[Therapeutic and prophylactic activity of isometamidium chloride in Boran cattle against Trypanosoma vivax transmitted by Glossina morsitans centralis]Therapeutic and prophylactic activity of isometamidium chloride in Boran cattle against Trypanosoma vivax transmitted by Glossina morsitans centralis
Silayo, R.S.Mamman, M.Moloo, S.K.Aliu, Y.O.Gray, M.A.Peregrine, A.S.[Response of Trypanosoma congolense in goats to single and double treatment with diminazene aceturate]Response of Trypanosoma congolense in goats to single and double treatment with diminazene aceturate

Six Boran cattle were infected with the drug-resistant Trypanosoma congolense IL 3338. At the first peak of parasitemia different groups of 200 teneral Glossina morsitans centralis were fed once on each animal, just prior to treatment with diminazene aceturate at a dose of 3.5 mg kg-1 body weight...


Diack, A.Moloo, S.K.Peregrine, A.S.[Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis]Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis
Hirumi, H.Hirumi, K.Peregrine, A.S.[Axenic culture of Trypanosoma congolense: Application to the detection of sensitivity levels of bloodstream Trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate]Axenic culture of Trypanosoma congolense: Application to the detection of sensitivity levels of bloodstream Trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate

Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kenedougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubatio...


Knoppe, T.N.Bauer, B.McDermott, John J.Peregrine, A.S.Mehlitz, D.Clausen, P.H.[Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test]Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test

A study was carried out to determine whether a drug-resistant trypanosome population could influence the survival of a drug-sensitive population in mixed infections in goats. To identify both populations during the course of a mixed infection, a system for distinguishing them was developed; using...


Burudi, E.M.E.Peregrine, A.S.Majiwa, P.A.O.Mbiuki, S.M.Murphy, N.B.[Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats]Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats
Mamman, M.Moloo, S.K.Peregrine, A.S.[Relapse of Trypanosoma congolense infection in goats after diminazene aceturate is not a result of invasion of the central nervous system]Relapse of Trypanosoma congolense infection in goats after diminazene aceturate is not a result of invasion of the central nervous system

Field studies were conducted to assess the occurrence of resistance to isometamidium chloride and diminazene aceturate in trypanosomes infecting cattle in Kenedougou Province of Burkina Faso. Forty-five of the 166 villages in Kenedougou were randomly sampled and visited to assess livestock numb...


McDermott, John J.Woitag, T.Sidibe, I.Bauer, B.Diarra, B.Ouédraogo, D.Kamuanga, M.Peregrine, A.S.Eisler, M.C.Zessin, K.H.[Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso]Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso

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