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Drug resistance in trypanosomes is increasingly being recognised as a constraint to livestock production in many parts of Africa. However the long-term stability of such resistance is unclear and has therefore been investigated over a 4-year period at a site in Ethiopia. The result shows that the...


Peregrine, A.S.Majiwa, P.A.O.Rowlands, G.J.[Long-term occurrence of multiple drug resistance in Trypanosoma congolense at Ghibe, Ethiopia]Long-term occurrence of multiple drug resistance in Trypanosoma congolense at Ghibe, Ethiopia

Characterising the drug susceptibility of trypanosomes that are pathogenic for domestic livestock has for many years been carried out either in vivo, using large or small animals, or by using various in vitro cultivation methodologies (Peregrine, 1994). Thus, adaptation to, and multiplication of ...


Peregrine, A.S.Wells, C.W.Wilkes, J.M.[Methods for detection of drug resistance in trypanosomes - new developments?]Methods for detection of drug resistance in trypanosomes - new developments?

Trypanosomosis remains one of the biggest impediments to the Development of the livestock industry in sub-Saharan Africa while it is likely that a vaccine for this disease could be found in the future, none is presently available. Mean-while different strategies are being followed to control this...


Majiwa, P.A.O.Konde, V.Souza, M. dePeregrine, A.S.Maina, M.[Molecular approaches to the identification of DNA markers for drug resistance in Trypanosoma congolense]Molecular approaches to the identification of DNA markers for drug resistance in Trypanosoma congolense

Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalenc...


Eisler, M.C.McDermott, John J.Mdachi, R.Murilla, G.Sinyangwe, L.Mubanga, J.Machila, N.Mbwambo, H.Coleman, P.G.Clausen, P.H.Bauer, B.Sidibe, I.Geerts, S.Holmes, P.H.Peregrine, A.S.[Rapid method for the assessment of trypanocidal drug resistance in the field]Rapid method for the assessment of trypanocidal drug resistance in the field

Chemotherapy is the single most important strategy for the control of trypanosomosis in African livestock. Trypanocidal drug resistance is a growing problem across much of sub-Saharan Africa and increasingly recognised as a major threat to livestock production. It is therefore of pressing importa...


Coleman, P.G.Eisler, M.C.McDermott, John J.Murphy, N.B.Majiwa, P.A.O.Peregrine, A.S.[Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense]Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense

The FAO/IAEA Trypanosomiasis Direct Antigen-ELISA kit has been distributed to scientists holding research contracts under an IAEA Co-ordinated Research Programme in 14 sub-Saharan African countries. It is intended for improved diagnosis of bovine tsetse-transmitted trypanosomiasis as an aid to e...


Eisler, M.C.Lessard, P.Moloo, D.Masake, R.A.Peregrine, A.S.[Sensitivity and specificity of antigen-capture ELISAs for diagnosis of Trypanosoma congolense and Trypanosoma vivax infections in cattle]Sensitivity and specificity of antigen-capture ELISAs for diagnosis of Trypanosoma congolense and Trypanosoma vivax infections in cattle

Tsetse-transmitted trypanosomosis affects cattle production over approximately 10 million km2 of Africa. In these areas, trypanocidal drugs, both prophylactic and curative, are the most widely used methods of trypanosomosis control. However, resistance of trypanosomes to the 3 trypanocidal drugs ...


McDermott, John J.Coleman, P.G.Eisler, M.C.Peregrine, A.S.[The effects of resistance to trypanocidal drugs on trypanosome transmission]The effects of resistance to trypanocidal drugs on trypanosome transmission

Isometamidium chloride is the most important chemoprophylactic agent used in the control of African bovine trypanosomiasis, although breakdowns in prophylaxis have been observed in the field. It is not usually apparent whether these breakdowns are due to inadequate drug dosage regimens, or to the...


Eisler, M.C.Maloo, S.H.Peregrine, A.S.Holmes, P.H.Thorpe, W.R.[Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya]Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya
Peregrine, A.S.Fasogbon, I.Scott, J.R.Knowles, G.Moloo, S.K.[Trypanosoma congolense: Clonal variation in expression of resistance to isometamidium chloride and diminazene aceturate]Trypanosoma congolense: Clonal variation in expression of resistance to isometamidium chloride and diminazene aceturate
Rowlands, G.J.Authié, E.D'Ieteren, G.D.M.Leak, S.G.A.Mulatu, W.Nagda, S.M.Peregrine, A.S.[An epidemiological study of recurrent trypanosome infection in East African Zebu cattle and its association with drug resistance]An epidemiological study of recurrent trypanosome infection in East African Zebu cattle and its association with drug resistance

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