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Experiments were carried out in goats to determine the frequency with which diminazene-resistant trypanosomes occur in parasite populations before and after the intramuscular treatment of the goats with diminazene aceturate. Trypanosoma congolense IL3274, a diminazene-resistant clone, was used to...


Mamman, M.Williams, D.J.L.Murphy, N.B.Peregrine, A.S.[Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense]Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense
Mamman, M.Katende, J.Moloo, S.K.Peregrine, A.S.[Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats]Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats

Diminazene aceturate is one of a limited number of drugs currently being used in animals to treat the tsetse fly-transmitted protozoal disease, African trypanosomiasis. Efficacy of the drug at the recommended single IM administered doses of 3.5 and 7.0 mg/kg of body weight is widely acknowledged....


Mamman, M.McKeever, Declan J.Aliu, Y.O.Peregrine, A.S.[Pharmacokinetics of diminazene in plasma and lymph of goats]Pharmacokinetics of diminazene in plasma and lymph of goats
Peregrine, A.S.Mamman, M.[A simple method for repeated sampling of lumbar cerebrospinal fluid in goats]A simple method for repeated sampling of lumbar cerebrospinal fluid in goats
Silayo, R.S.Mamman, M.Moloo, S.K.Aliu, Y.O.Gray, M.A.Peregrine, A.S.[Response of Trypanosoma congolense in goats to single and double treatment with diminazene aceturate]Response of Trypanosoma congolense in goats to single and double treatment with diminazene aceturate

A study was carried out to determine whether a drug-resistant trypanosome population could influence the survival of a drug-sensitive population in mixed infections in goats. To identify both populations during the course of a mixed infection, a system for distinguishing them was developed; using...


Burudi, E.M.E.Peregrine, A.S.Majiwa, P.A.O.Mbiuki, S.M.Murphy, N.B.[Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats]Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats
Mamman, M.Moloo, S.K.Peregrine, A.S.[Relapse of Trypanosoma congolense infection in goats after diminazene aceturate is not a result of invasion of the central nervous system]Relapse of Trypanosoma congolense infection in goats after diminazene aceturate is not a result of invasion of the central nervous system

Studies on infections with drug-resistant trypanosomes indicate that the majority of parasites in a population are sensitive to the drug dose used to select the population (Mamman et al., 1993). This study was initiated to examine whether a drug-resistant trypanosome population could influence th...


Burudi, E.M.E.Peregrine, A.S.Majiwa, P.A.O.Murphy, N.B.[Evaluation of response to treatment of mixed trypanosome infection in goats using the polymerase chain reaction]Evaluation of response to treatment of mixed trypanosome infection in goats using the polymerase chain reaction

A study was undertaken to compare the absorption and distribution of the antitrypanosomal drug diminazene aceturate in plasma, cerebrospinal fluid (CSF) and lymph of goats. The study comprised three groups of three goats each. Animals in each group were treated with a single intramuscular dose of...


Mamman, M.McKeever, Declan J.Peregrine, A.S.[Comparative pharmacokinetics of diminazene in plasma, cerebrospinal fluid and lymph of goats]Comparative pharmacokinetics of diminazene in plasma, cerebrospinal fluid and lymph of goats

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