Six Boran cattle were infected with the drug-resistant Trypanosoma congolense IL 3338. At the first peak of parasitemia different groups of 200 teneral Glossina morsitans centralis were fed once on each animal, just prior to treatment with diminazene aceturate at a dose of 3.5 mg kg-1 body weight...
Diack, A.
,
Moloo, S.K.
,
Peregrine, A.S.
,
[Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis]
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Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis
Hirumi, H.
,
Hirumi, K.
,
Peregrine, A.S.
,
[Axenic culture of Trypanosoma congolense: Application to the detection of sensitivity levels of bloodstream Trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate]
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Axenic culture of Trypanosoma congolense: Application to the detection of sensitivity levels of bloodstream Trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate
Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kenedougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubatio...
Knoppe, T.N.
,
Bauer, B.
,
McDermott, John J.
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Peregrine, A.S.
,
Mehlitz, D.
,
Clausen, P.H.
,
[Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test]
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Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test
Gray, M.A.
,
Kimarua, R.W.
,
Peregrine, A.S.
,
[Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya]
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Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya
In a cross-sectional study carried out in June 1994, 486 cattle from 50 randomly selected dairy farms in the vicinity of Kampala, Uganda, were examined for trypanosome infections. The trypanosome prevalence (either positive with the haematocrit centrifugation technique [HCT] and/or the mini-anion...
Clausen, P.H.
,
Schares, G.
,
Patzelt, R.J.
,
Poetzsch, C.J.
,
Scheer, A.
,
Kakaire, D.
,
Olila, D.
,
Peregrine, A.S.
,
McDermott, John J.
,
Mehlitz, D.
,
[PCR and DNA-probe hybridization to assess the efficacy of therapeutic and prophylactic isometamidium treatment in Trypanosoma spp. - infected dairy cattle in peri-urban Kampala, Uganda]
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PCR and DNA-probe hybridization to assess the efficacy of therapeutic and prophylactic isometamidium treatment in Trypanosoma spp. - infected dairy cattle in peri-urban Kampala, Uganda
Control of trypanosomes in cattle, sheep and goats in endemic areas has depended largely on the use of chemotherapeutic or chemoprophylactic agents. One such agent is homidium. The normal use of homidium has been in the treatment of infections due to both Trypanosoma congolense and T.vivax in cat...
Murilla, G.A.
,
Peregrine, A.S.
,
Holmes, P.H.
,
Eisler, M.C.
,
Ndung'u, J.M.
,
[Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle]
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Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle
Waitumbi, J.N.
,
Murphy, N.B.
,
Peregrine, A.S.
,
[Genotype and drug-resistance phenotype of Trypanosoma evansi originating from camels in Northern Kenya]
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Genotype and drug-resistance phenotype of Trypanosoma evansi originating from camels in Northern Kenya
Peregrine, A.S.
,
Ogunyemi, O.
,
Whitelaw, D.D.
,
Holmes, P.H.
,
Moloo, S.K.
,
Hirumi, H.
,
Urquhart, G.M.
,
Murray, M.
,
[Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense]
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Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense
Interaction of the trypanocide isometamidium chloride with components of Trypanosoma congolense results in characteristic shifts in the intrinsic fluorescence of the drug. The specificity of this interaction was investigated by analysing the effects of various physiochemical manipulations on its ...
Wilkes, J.M.
,
Peregrine, A.S.
,
Zilberstein, D.
,
[The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence]
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The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence
Ndoutamia, G.
,
Moloo, S.K.
,
Murphy, N.B.
,
Peregrine, A.S.
,
[Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense]
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Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense