Chemotherapy is the single most important strategy for the control of trypanosomosis in African livestock. Trypanocidal drug resistance is a growing problem across much of sub-Saharan Africa and increasingly recognised as a major threat to livestock production. It is therefore of pressing importa...
Coleman, P.G.
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Eisler, M.C.
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McDermott, John J.
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Murphy, N.B.
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Majiwa, P.A.O.
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Peregrine, A.S.
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[Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense]
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Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense
The FAO/IAEA Trypanosomiasis Direct Antigen-ELISA kit has been distributed to scientists holding research contracts under an IAEA Co-ordinated Research Programme in 14 sub-Saharan African countries. It is intended for improved diagnosis of bovine tsetse-transmitted trypanosomiasis as an aid to e...
Eisler, M.C.
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Lessard, P.
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Moloo, D.
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Masake, R.A.
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Peregrine, A.S.
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[Sensitivity and specificity of antigen-capture ELISAs for diagnosis of Trypanosoma congolense and Trypanosoma vivax infections in cattle]
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Sensitivity and specificity of antigen-capture ELISAs for diagnosis of Trypanosoma congolense and Trypanosoma vivax infections in cattle
Tsetse-transmitted trypanosomosis affects cattle production over approximately 10 million km2 of Africa. In these areas, trypanocidal drugs, both prophylactic and curative, are the most widely used methods of trypanosomosis control. However, resistance of trypanosomes to the 3 trypanocidal drugs ...
McDermott, John J.
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Coleman, P.G.
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Eisler, M.C.
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Peregrine, A.S.
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[The effects of resistance to trypanocidal drugs on trypanosome transmission]
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The effects of resistance to trypanocidal drugs on trypanosome transmission
Isometamidium chloride is the most important chemoprophylactic agent used in the control of African bovine trypanosomiasis, although breakdowns in prophylaxis have been observed in the field. It is not usually apparent whether these breakdowns are due to inadequate drug dosage regimens, or to the...
Eisler, M.C.
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Maloo, S.H.
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Peregrine, A.S.
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Holmes, P.H.
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Thorpe, W.R.
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[Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya]
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Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya
Peregrine, A.S.
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Fasogbon, I.
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Scott, J.R.
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Knowles, G.
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Moloo, S.K.
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[Trypanosoma congolense: Clonal variation in expression of resistance to isometamidium chloride and diminazene aceturate]
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Trypanosoma congolense: Clonal variation in expression of resistance to isometamidium chloride and diminazene aceturate
Rowlands, G.J.
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Authié, E.
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D'Ieteren, G.D.M.
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Leak, S.G.A.
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Mulatu, W.
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Nagda, S.M.
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Peregrine, A.S.
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[An epidemiological study of recurrent trypanosome infection in East African Zebu cattle and its association with drug resistance]
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An epidemiological study of recurrent trypanosome infection in East African Zebu cattle and its association with drug resistance
The extent and significance of trypanocidal drug resistance was investigated in priority areas of three East and Southern African Countries under a project. The project was built on the results of two previous projects. Existing methods currently available for the demonstration of drug-resistance...
Eisler, M.C.
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Ndung'u, J.M.
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Murilla, G.
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Mdachi, R.M.
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Mbwambo, H.
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Sinyangwe, L.
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Machila, N.
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Delespaux, V.
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Geerts, S.
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Brandt, J.
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Peregrine, A.S.
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McDermott, John J.
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Holmes, P.H.
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[Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa]
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Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa
Isometamidium chloride (Samorin Trypamidium), diminazene aceturate (Berenil, Veriben), homidium chloride (Novidium), homidium bromide (Ethidium) and the salts of quinapyramine (Trypacide, Triquin) are all anti-trypanosomal compounds that are routinely used in domestic livestock. However, the salt...
Peregrine, A.S.
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Kemei, S.
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Ndoutamia, G.
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[Cross-resistance phenotypes associated with induction of resistance to isometamidium chloride and quinapyramine sulphate in Trypanosoma congolense]
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Cross-resistance phenotypes associated with induction of resistance to isometamidium chloride and quinapyramine sulphate in Trypanosoma congolense
The peri-urban dairy production systems in Uganda, located in the subhumid agro-ecological zone with medium rainfall have a high potential for livestock production (Walsche et al., 1991; Winrock, 1992), but medium tsetse challenge and the associated trypanosomiasis risk may adversely affect dairy...
Patzelt, R.J.
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Schares, G.
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Peregrine, A.S.
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Lessard, P.
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Laker, C.
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Leak, S.G.A.
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Mehlitz, D.
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[Design of collaborative studies to assess the impact of diseases on production: Case study of trypanosomiasis in peri-urban dairy production systems in Uganda]
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Design of collaborative studies to assess the impact of diseases on production: Case study of trypanosomiasis in peri-urban dairy production systems in Uganda
Studies on infections with drug-resistant trypanosomes indicate that the majority of parasites in a population are sensitive to the drug dose used to select the population (Mamman et al., 1993). This study was initiated to examine whether a drug-resistant trypanosome population could influence th...
Burudi, E.M.E.
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Peregrine, A.S.
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Majiwa, P.A.O.
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Murphy, N.B.
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[Evaluation of response to treatment of mixed trypanosome infection in goats using the polymerase chain reaction]
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Evaluation of response to treatment of mixed trypanosome infection in goats using the polymerase chain reaction