A study was undertaken to compare the absorption and distribution of the antitrypanosomal drug diminazene aceturate in plasma, cerebrospinal fluid (CSF) and lymph of goats. The study comprised three groups of three goats each. Animals in each group were treated with a single intramuscular dose of...
Mamman, M.
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McKeever, Declan J.
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Peregrine, A.S.
,
[Comparative pharmacokinetics of diminazene in plasma, cerebrospinal fluid and lymph of goats]
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Comparative pharmacokinetics of diminazene in plasma, cerebrospinal fluid and lymph of goats
Two clones of Trypanosoma (Nannomonas) congolense were derived one from the other by growth in mice and administration of increasing sub-curative doses of isometamidium chloride. One of the clones thus became approximately 10x more tolerant to the trypanocide than the other mRNA from the two clon...
Majiwa, P.A.O.
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Maina, M.
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Peregrine, A.S.
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Kasumba, I.
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[Comparative molecular analysis of isogenic clones of Trypanosoma (Nanommonas) congolense that differ in their response to isometamidium chloride]
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Comparative molecular analysis of isogenic clones of Trypanosoma (Nanommonas) congolense that differ in their response to isometamidium chloride
It is useful to be able to estimate the incidence of new infections in cattle exposed to a high challenge of drug resistance trypanosomes; with this information the impact of an intervention that improves the control of trypanosomosis can be better understood. Approximately 750 Ethiopian Highland...
Twelve traditional herds of cattle in the area of Boundiali, northern Cote d'Ivoire, were examined monthly from 1990 to 1992 for the presence of trypanosomes. The herds were randomised into 3 treatment groups, cattle in 4 herds received diminazene aceturate at 3.5 or 7 mg/kg body weight (b.w.) wh...
To investigate the importance of trypanosomosis, resistance to trypanocidal drugs and the potential impact of integrated control measures on these factors, a 3-phase study was initiated. The first phase was a cross-sectional study in which tsetse apparent density, cattle trypanosome prevalence, t...
McDermott, John J.
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Sidibe, I.
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Bauer, B.
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Diarra, B.
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Clausen, P.H.
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Woitay, T.
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Ouédraogo, T.
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Kamuanga, M.
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Peregrine, A.S.
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Eisler, M.C.
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Mehlitz, D.
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[Field studies on the Development and impact of drug resistant animal trypanosomes in market oriented production systems in the Southern Guinean zone of West Africa]
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Field studies on the Development and impact of drug resistant animal trypanosomes in market oriented production systems in the Southern Guinean zone of West Africa
Isometamidium chloride (Samorin, Trypanidium is a phenanthridine-aromatic amidine that is commonly used in cattle as a prophylactic agent against trypanosomiasis. Although the compound has been used for over 30 years, very little is known about its mode of action. Various workers have demonstrate...
Peregrine, A.S.
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Eisler, M.C.
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Flynn, J.N.
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Katende, J.
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Gault, E.A.
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Kinabo, L.D.B.
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Homes, P.H.
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[Generation of monoclonal antibodies to the anti-trypanosomal drug Samorin]
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Generation of monoclonal antibodies to the anti-trypanosomal drug Samorin
Besides the in vitro test, two tests are very commonly used for the detection of trypanocidal drug resistance: the tests in mice and in ruminants. Since it has been shown that several parameters such as the number of trypanosomes inoculated and the time of treatment might influence the outcome of...
Geerts, S.
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Ndung'u, J.M.
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Murilla, G.
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Mbwambo, H.
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Sirryangwe, L.
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Machila, N.
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Delespaux, V.
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Brandt, J.
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Peregrine, A.S.
,
McDermott, John J.
,
Holmes, P.H.
,
Eisler, M.C.
,
[In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants]
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In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants