An average of 840 East African Zebu cattle from nine herds in the Ghibe Valley, southwest Ethiopia were monitored from 1986 to 1990. Each month blood samples were collected from analysis of packed red cell volume and detection of trypanosomes. Animals were found to be parasitaemic and with a PCV ...
Rowlands, G.J.
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Mulatu, W.
,
Authie, A.
,
D'Ieteren, G.D.M.
,
Leak, S.G.A.
,
Nagda, S.M.
,
Peregrine, A.S.
,
[Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 2. Factors associated with variations in trypanosome prevalence, incidence of new infections and prevalence of recurrent infections]
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Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 2. Factors associated with variations in trypanosome prevalence, incidence of new infections and prevalence of recurrent infections
The sensitivity of seven populations of T. congolense to the salts of three trypanocides, diminazene, isometamidium and homidium, were determined in vitro using in vitro-derived metacyclic trypanosomes. The trypanosomes were incubated at 35 degree centigrade for 48 hours with various drug concent...
Gray, M.A.
,
Peregrine, A.S.
,
[An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes]
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An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes
Cattle from 50 farms in Mukono County, Uganda, were monitored for trypanosomes every second month over an 18-month period (1995–1996) by mini-anion exchange chromatography and haematocrit centrifugation techniques. Eighteen trypanosome isolates collected from cattle during this period were charac...
Olila, D.
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McDermott, John J.
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Eisler, M.C.
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Mitema, E.S.
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Patzelt, R.J.
,
Clausen, P.H.
,
Poetzsch, C.J.
,
Zessin, K.H.
,
Mehlitz, D.
,
Peregrine, A.S.
,
[Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda]
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Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda
Field studies were conducted to assess the occurrence of resistance to isometamidium chloride and diminazene aceturate in trypanosomes infecting cattle in Kenedougou Province of Burkina Faso. Forty-five of the 166 villages in Kenedougou were randomly sampled and visited to assess livestock numb...
McDermott, John J.
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Woitag, T.
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Sidibe, I.
,
Bauer, B.
,
Diarra, B.
,
Ouédraogo, D.
,
Kamuanga, M.
,
Peregrine, A.S.
,
Eisler, M.C.
,
Zessin, K.H.
,
[Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso]
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Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso
A method is described for calculating new infection incidence from monthly field data collected between April 1994 and February 1998 from an average of 770 Ethiopian Highland Zebu cattle maintained under traditional management in the Ghibe valley, southwest Ethiopia and exposed to a high challeng...
Rowlands, G.J.
,
Leak, S.G.A.
,
Peregrine, A.S.
,
Nagda, S.M.
,
Mulatu, W.
,
D'Ieteren, G.D.M.
,
[The incidence of new and the prevalence and persistence of recurrent trypanosome infections in cattle in southewest Ethiopia exposed to a high challenge with drug-resistant parasites]
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The incidence of new and the prevalence and persistence of recurrent trypanosome infections in cattle in southewest Ethiopia exposed to a high challenge with drug-resistant parasites
Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...
Eisler, M.C.
,
Brandt, J.
,
Bauer, B.
,
Clausen, P.H.
,
Delespaux, V.
,
Holmes, P.H.
,
Ilemobade, A.
,
Machila, N.
,
Mbwambo, H.
,
McDermott, John J.
,
Mehlitz, D.
,
Murilla, G.
,
Ndung'u, J.M.
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Peregrine, A.S.
,
Sidibe, I.
,
Sinyangwe, L.
,
Geerts, S.
,
[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]
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Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle
Two groups of five Boran (Bos indicus) cattle were infected with one of two populations of Trypanosoma congolense; one drug-sensitive (IL1180), and one drug-resistant (IL3330). The animals were then treated intramuscularly with homidium bromide at a dose rate of 1.0 mg kg - bodyweight 7 days afte...
Murilla, G.A.
,
Peregrine, A.S.
,
Ndung'u, J.M.
,
Holmes, P.H.
,
Eisler, M.C.
,
[The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle]
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The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle