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The frequency of trypanosomes resistant to diminazene aceturate at a dose of 26 mg/kg of bwt was investigated for populations of Trypanosoma congolense IL 3274 which reappeared in infected mice after intraperitoneal treatment with diminazene aceturate at the same dosage. At inoculum sizes of 102,...


Mamman, M.Gettinby, N.B.Murphy, N.B.Kemei, S.Peregrine, A.S.[Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate]Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate
Zilberstein, D.Wilkes, J.M.Hirumi, H.Peregrine, A.S.[Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense]Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense

In light of the current problems and limitations of chemotherapy for trypanosomiasis in domestic livestock and human beings, this workshop was conducted to discuss research aimed at developing new trypanocides. Because of the scarcity of information on the phenotypic and genetic basis of drug res...


Peregrine, A.S.[Chemotherapy for trypanosomiasis. Proceedings of a workshop]Chemotherapy for trypanosomiasis. Proceedings of a workshop

Diminazene aceturate is one of a limited number of drugs currently being used in animals to treat the tsetse fly-transmitted protozoal disease, African trypanosomiasis. Efficacy of the drug at the recommended single IM administered doses of 3.5 and 7.0 mg/kg of body weight is widely acknowledged....


Mamman, M.McKeever, Declan J.Aliu, Y.O.Peregrine, A.S.[Pharmacokinetics of diminazene in plasma and lymph of goats]Pharmacokinetics of diminazene in plasma and lymph of goats
Peregrine, A.S.Hirumi, H.Zilberstein, D.[Fluorescence analysis of the interaction of isometamidium (Samorin) with Trypanosoma congolense]Fluorescence analysis of the interaction of isometamidium (Samorin) with Trypanosoma congolense
Mamman, M.Gettinby, G.Murphy, N.B.Kemei, S.Peregrine, A.S.[Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene]Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene
Peregrine, A.S.Moloo, S.K.Whitelaw, D.D.[Differences in sensitivity of Kenyan Trypanosoma vivax populations to the prophylactic and therapeutic actions of isometamidium chloride in Boran cattle]Differences in sensitivity of Kenyan Trypanosoma vivax populations to the prophylactic and therapeutic actions of isometamidium chloride in Boran cattle

Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognize...


Peregrine, A.S.Eisler, M.C.Katende, J.Flynn, J.N.Gault, E.A.Kinabo, L.D.B.Holmes, P.H.[Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium]Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium
Peregrine, A.S.Moloo, S.K.Whitelaw, D.D.[Therapeutic and prophylactic activity of isometamidium chloride in Boran cattle against Trypanosoma vivax transmitted by Glossina morsitans centralis]Therapeutic and prophylactic activity of isometamidium chloride in Boran cattle against Trypanosoma vivax transmitted by Glossina morsitans centralis

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