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The frequency of trypanosomes resistant to diminazene aceturate at a dose of 26 mg/kg of bwt was investigated for populations of Trypanosoma congolense IL 3274 which reappeared in infected mice after intraperitoneal treatment with diminazene aceturate at the same dosage. At inoculum sizes of 102,...


Mamman, M.Gettinby, N.B.Murphy, N.B.Kemei, S.Peregrine, A.S.[Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate]Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate
Zilberstein, D.Wilkes, J.M.Hirumi, H.Peregrine, A.S.[Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense]Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense

Diminazene aceturate is one of a limited number of drugs currently being used in animals to treat the tsetse fly-transmitted protozoal disease, African trypanosomiasis. Efficacy of the drug at the recommended single IM administered doses of 3.5 and 7.0 mg/kg of body weight is widely acknowledged....


Mamman, M.McKeever, Declan J.Aliu, Y.O.Peregrine, A.S.[Pharmacokinetics of diminazene in plasma and lymph of goats]Pharmacokinetics of diminazene in plasma and lymph of goats
Peregrine, A.S.Hirumi, H.Zilberstein, D.[Fluorescence analysis of the interaction of isometamidium (Samorin) with Trypanosoma congolense]Fluorescence analysis of the interaction of isometamidium (Samorin) with Trypanosoma congolense
Mamman, M.Gettinby, G.Murphy, N.B.Kemei, S.Peregrine, A.S.[Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene]Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene
Peregrine, A.S.Moloo, S.K.Whitelaw, D.D.[Differences in sensitivity of Kenyan Trypanosoma vivax populations to the prophylactic and therapeutic actions of isometamidium chloride in Boran cattle]Differences in sensitivity of Kenyan Trypanosoma vivax populations to the prophylactic and therapeutic actions of isometamidium chloride in Boran cattle

Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognize...


Peregrine, A.S.Eisler, M.C.Katende, J.Flynn, J.N.Gault, E.A.Kinabo, L.D.B.Holmes, P.H.[Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium]Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium
Peregrine, A.S.Moloo, S.K.Whitelaw, D.D.[Therapeutic and prophylactic activity of isometamidium chloride in Boran cattle against Trypanosoma vivax transmitted by Glossina morsitans centralis]Therapeutic and prophylactic activity of isometamidium chloride in Boran cattle against Trypanosoma vivax transmitted by Glossina morsitans centralis

Six Boran cattle were infected with the drug-resistant Trypanosoma congolense IL 3338. At the first peak of parasitemia different groups of 200 teneral Glossina morsitans centralis were fed once on each animal, just prior to treatment with diminazene aceturate at a dose of 3.5 mg kg-1 body weight...


Diack, A.Moloo, S.K.Peregrine, A.S.[Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis]Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis

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