Blood samples were collected from parasitaemic cattle in the Ghibe Valley, Ethiopia, frozen in liquid nitrogen and transported to Nairobi, Kenya. Twelve of the stabilates were inoculated into individual Boran (Bos indicus) calves and characterised for their sensitivity, in turn, to diminazene ace...
Codjia, V.
,
Mulatu, W.
,
Majiwa, P.A.O.
,
Leak, S.G.A.
,
Rowlands, G.J.
,
Authié, E.
,
D'Ieteren, G.D.M.
,
Peregrine, A.S.
,
[Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of population of Trypanosoma congolense resistant to diminazene, isometamidium and homidium]
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Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of population of Trypanosoma congolense resistant to diminazene, isometamidium and homidium
The sensitivity of seven populations of T. congolense to the salts of three trypanocides, diminazene, isometamidium and homidium, were determined in vitro using in vitro-derived metacyclic trypanosomes. The trypanosomes were incubated at 35 degree centigrade for 48 hours with various drug concent...
Gray, M.A.
,
Peregrine, A.S.
,
[An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes]
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An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes
Eisler, M.C.
,
Arowolo, R.O.A.
,
Gault, E.A.
,
Moloo, S.K.
,
Holmes, P.H.
,
Peregrine, A.S.
,
[Isometamidium concentrations in the sera of Boran cattle. Correlation with prophylaxis against tsetse-transmitted Trypanosoma congolense]
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Isometamidium concentrations in the sera of Boran cattle. Correlation with prophylaxis against tsetse-transmitted Trypanosoma congolense
Sutherland, I.A.
,
Moloo, S.K.
,
Holmes, P.H.
,
Peregrine, A.S.
,
[Therapeutic and prophylactic activity of isometamidium chloride against a tsetse-transmitted drug-resistant clone of Trypanosoma congolense in Boran cattle]
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Therapeutic and prophylactic activity of isometamidium chloride against a tsetse-transmitted drug-resistant clone of Trypanosoma congolense in Boran cattle
Experiments were carried out in goats to determine the frequency with which diminazene-resistant trypanosomes occur in parasite populations before and after the intramuscular treatment of the goats with diminazene aceturate. Trypanosoma congolense IL3274, a diminazene-resistant clone, was used to...
Mamman, M.
,
Williams, D.J.L.
,
Murphy, N.B.
,
Peregrine, A.S.
,
[Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense]
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Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense
Mamman, M.
,
Katende, J.
,
Moloo, S.K.
,
Peregrine, A.S.
,
[Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats]
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Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats
The frequency of trypanosomes resistant to diminazene aceturate at a dose of 26 mg/kg of bwt was investigated for populations of Trypanosoma congolense IL 3274 which reappeared in infected mice after intraperitoneal treatment with diminazene aceturate at the same dosage. At inoculum sizes of 102,...
Mamman, M.
,
Gettinby, N.B.
,
Murphy, N.B.
,
Kemei, S.
,
Peregrine, A.S.
,
[Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate]
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Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate
Peregrine, A.S.
,
Knowles, G.
,
Ibitayo, A.I.
,
Scott, J.R.
,
Moloo, S.K.
,
Murphy, N.B.
,
[Variation in resistance to isometamidium chloride and diminazene aceturate by clones derived from a stock of Trypanosoma congolense]
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Variation in resistance to isometamidium chloride and diminazene aceturate by clones derived from a stock of Trypanosoma congolense
Zilberstein, D.
,
Wilkes, J.M.
,
Hirumi, H.
,
Peregrine, A.S.
,
[Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense]
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Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense
Peregrine, A.S.
,
Hirumi, H.
,
Zilberstein, D.
,
[Fluorescence analysis of the interaction of isometamidium (Samorin) with Trypanosoma congolense]
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Fluorescence analysis of the interaction of isometamidium (Samorin) with Trypanosoma congolense