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Characterising the drug susceptibility of trypanosomes that are pathogenic for domestic livestock has for many years been carried out either in vivo, using large or small animals, or by using various in vitro cultivation methodologies (Peregrine, 1994). Thus, adaptation to, and multiplication of ...


Peregrine, A.S.Wells, C.W.Wilkes, J.M.[Methods for detection of drug resistance in trypanosomes - new developments?]Methods for detection of drug resistance in trypanosomes - new developments?

Tsetse-transmitted trypanosomosis affects cattle production over approximately 10 million km2 of Africa. In these areas, trypanocidal drugs, both prophylactic and curative, are the most widely used methods of trypanosomosis control. However, resistance of trypanosomes to the 3 trypanocidal drugs ...


McDermott, John J.Coleman, P.G.Eisler, M.C.Peregrine, A.S.[The effects of resistance to trypanocidal drugs on trypanosome transmission]The effects of resistance to trypanocidal drugs on trypanosome transmission

The extent and significance of trypanocidal drug resistance was investigated in priority areas of three East and Southern African Countries under a project. The project was built on the results of two previous projects. Existing methods currently available for the demonstration of drug-resistance...


Eisler, M.C.Ndung'u, J.M.Murilla, G.Mdachi, R.M.Mbwambo, H.Sinyangwe, L.Machila, N.Delespaux, V.Geerts, S.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.[Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa]Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa

Twelve traditional herds of cattle in the area of Boundiali, northern Cote d'Ivoire, were examined monthly from 1990 to 1992 for the presence of trypanosomes. The herds were randomised into 3 treatment groups, cattle in 4 herds received diminazene aceturate at 3.5 or 7 mg/kg body weight (b.w.) wh...


Coulibaly, L.Hecker, P.A.Krebs, H.A.Rowlands, G.J.D'Ieteren, G.D.M.Leak, S.G.A.Peregrine, A.S.Nagda, S.M.[Failure of trypanocidal drugs to cure trypanosome infections in cattle in Boundiali District, northern Cote d'Ivoire]Failure of trypanocidal drugs to cure trypanosome infections in cattle in Boundiali District, northern Cote d'Ivoire

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