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Blood samples were collected from parasitaemic cattle in the Ghibe Valley, Ethiopia, frozen in liquid nitrogen and transported to Nairobi, Kenya. Twelve of the stabilates were inoculated into individual Boran (Bos indicus) calves and characterised for their sensitivity, in turn, to diminazene ace...


Codjia, V.Mulatu, W.Majiwa, P.A.O.Leak, S.G.A.Rowlands, G.J.Authié, E.D'Ieteren, G.D.M.Peregrine, A.S.[Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of population of Trypanosoma congolense resistant to diminazene, isometamidium and homidium]Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of population of Trypanosoma congolense resistant to diminazene, isometamidium and homidium

An average of 840 East African Zebu cattle from nine herds in the Ghibe Valley, southwest Ethiopia were monitored from 1986 to 1990. Each month blood samples were collected from analysis of packed red cell volume and detection of trypanosomes. Animals were found to be parasitaemic and with a PCV ...


Rowlands, G.J.Mulatu, W.Authie, A.D'Ieteren, G.D.M.Leak, S.G.A.Nagda, S.M.Peregrine, A.S.[Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 2. Factors associated with variations in trypanosome prevalence, incidence of new infections and prevalence of recurrent infections]Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 2. Factors associated with variations in trypanosome prevalence, incidence of new infections and prevalence of recurrent infections
Peregrine, A.S.[Factors influencing the duration of isometamidium prophylaxis against bovine trypanosomiasis.]Factors influencing the duration of isometamidium prophylaxis against bovine trypanosomiasis.

Cattle from 50 farms in Mukono County, Uganda, were monitored for trypanosomes every second month over an 18-month period (1995–1996) by mini-anion exchange chromatography and haematocrit centrifugation techniques. Eighteen trypanosome isolates collected from cattle during this period were charac...


Olila, D.McDermott, John J.Eisler, M.C.Mitema, E.S.Patzelt, R.J.Clausen, P.H.Poetzsch, C.J.Zessin, K.H.Mehlitz, D.Peregrine, A.S.[Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda]Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda

In light of the current problems and limitations of chemotherapy for trypanosomiasis in domestic livestock and human beings, this workshop was conducted to discuss research aimed at developing new trypanocides. Because of the scarcity of information on the phenotypic and genetic basis of drug res...


Peregrine, A.S.[Chemotherapy for trypanosomiasis. Proceedings of a workshop]Chemotherapy for trypanosomiasis. Proceedings of a workshop

In 1986 a project was set up to determine the constraints to production of Zebu cattle under trypanosomiasis risk in the Ghibe valley. Approximately 1800 East African Zebu cattle (EAZC) were resident within the Ghibe valleey during the experimental period (1986 - 1992) and were maintained under t...


Peregrine, A.S.Mulatu, W.Leak, S.G.A.Rowlands, G.J.[Epidemiology of bovine trypanosomiasis in the Ghibe Valley, Ethiopia: Multiple-drug resistance and its effective control]Epidemiology of bovine trypanosomiasis in the Ghibe Valley, Ethiopia: Multiple-drug resistance and its effective control

During this century livestock production has increased massively through the improved ability to diagnose, treat, control and prevent certain diseases. Despite these advances, disease remains a major constraint to livestock production and welfare throughout the world. In many instances, this is a...


Gu, Y.Gettinby, G.McKendrick, I.Murray, M.Peregrine, A.S.[Development of a decision support system for trypanocidal drug control of bovine trypanosomosis in Africa]Development of a decision support system for trypanocidal drug control of bovine trypanosomosis in Africa

Peregrine, A.S.Sutherland, I.A.Mutharia, L.Jamnadass, Ramni H.Gray, M.A.Codjia, V.Aliu, Y.O.Mamman, M.Silayo, R.D'Ieteren, G.D.M.Moloo, S.K.Murphy, N.B.[Overview of the chemotherapy research program at ILRAD]Overview of the chemotherapy research program at ILRAD

Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognize...


Peregrine, A.S.Eisler, M.C.Katende, J.Flynn, J.N.Gault, E.A.Kinabo, L.D.B.Holmes, P.H.[Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium]Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium

Field studies were conducted to assess the occurrence of resistance to isometamidium chloride and diminazene aceturate in trypanosomes infecting cattle in Kenedougou Province of Burkina Faso. Forty-five of the 166 villages in Kenedougou were randomly sampled and visited to assess livestock numb...


McDermott, John J.Woitag, T.Sidibe, I.Bauer, B.Diarra, B.Ouédraogo, D.Kamuanga, M.Peregrine, A.S.Eisler, M.C.Zessin, K.H.[Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso]Field studies of drug-resistant cattle trypanosomes in Kenedougou Province, Burkina Faso

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