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Blood samples were collected from parasitaemic cattle in the Ghibe Valley, Ethiopia, frozen in liquid nitrogen and transported to Nairobi, Kenya. Twelve of the stabilates were inoculated into individual Boran (Bos indicus) calves and characterised for their sensitivity, in turn, to diminazene ace...


Codjia, V.Mulatu, W.Majiwa, P.A.O.Leak, S.G.A.Rowlands, G.J.Authié, E.D'Ieteren, G.D.M.Peregrine, A.S.[Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of population of Trypanosoma congolense resistant to diminazene, isometamidium and homidium]Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of population of Trypanosoma congolense resistant to diminazene, isometamidium and homidium

An average of 840 East African Zebu cattle from nine herds in the Ghibe Valley, southwest Ethiopia were monitored from 1986 to 1990. Each month blood samples were collected from analysis of packed red cell volume and detection of trypanosomes. Animals were found to be parasitaemic and with a PCV ...


Rowlands, G.J.Mulatu, W.Authie, A.D'Ieteren, G.D.M.Leak, S.G.A.Nagda, S.M.Peregrine, A.S.[Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 2. Factors associated with variations in trypanosome prevalence, incidence of new infections and prevalence of recurrent infections]Epidemiology of bovine trypanosomiasis in the Ghibe Valley, southwest Ethiopia. 2. Factors associated with variations in trypanosome prevalence, incidence of new infections and prevalence of recurrent infections

The sensitivity of seven populations of T. congolense to the salts of three trypanocides, diminazene, isometamidium and homidium, were determined in vitro using in vitro-derived metacyclic trypanosomes. The trypanosomes were incubated at 35 degree centigrade for 48 hours with various drug concent...


Gray, M.A.Peregrine, A.S.[An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes]An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes

An isolate of T. vivax was collected from a naturally infected Zebu in French Guyana. The isolate was subsequently shown to produce pathogenic infections in both Taurine and Zebu cattle. However, its sensitivity of the population to diminazene aceturate and isometamidium chloride was determined s...


Desquesnes, M.Rocque, S. de laPeregrine, A.S.[French Guyanan stock of Trypanosoma vivax resistant to diminazene aceturate but sensitive to isometamidium chloride]French Guyanan stock of Trypanosoma vivax resistant to diminazene aceturate but sensitive to isometamidium chloride
Eisler, M.C.Arowolo, R.O.A.Gault, E.A.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Isometamidium concentrations in the sera of Boran cattle. Correlation with prophylaxis against tsetse-transmitted Trypanosoma congolense]Isometamidium concentrations in the sera of Boran cattle. Correlation with prophylaxis against tsetse-transmitted Trypanosoma congolense
Sutherland, I.A.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Therapeutic and prophylactic activity of isometamidium chloride against a tsetse-transmitted drug-resistant clone of Trypanosoma congolense in Boran cattle]Therapeutic and prophylactic activity of isometamidium chloride against a tsetse-transmitted drug-resistant clone of Trypanosoma congolense in Boran cattle

Experiments were carried out in goats to determine the frequency with which diminazene-resistant trypanosomes occur in parasite populations before and after the intramuscular treatment of the goats with diminazene aceturate. Trypanosoma congolense IL3274, a diminazene-resistant clone, was used to...


Mamman, M.Williams, D.J.L.Murphy, N.B.Peregrine, A.S.[Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense]Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense
Mamman, M.Katende, J.Moloo, S.K.Peregrine, A.S.[Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats]Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats

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