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The indirect MAP 1B ELISA based on the recombinant MAP 1B fragment of the immunodominant MAP 1 protein of Ehrlichia ruminantium is considered to be the most sensitive and specific assay for the serodiagnosis of heartwater. In this study, we evaluated its reliability in detecting exposure to E....
Three species of wild African ruminants. impala (Aepyceros melampus), sable (Hippotragus equinus, and tsessebe (Damaliscus lunatus), were experimentally inoculated with in vitro culture-derived Cowdria ruminantium organisms, the tick-borne causative agent of heartwater in domestic ruminants, to d...
A mathematical description of the transmission dynamics of the tick-borne infection Cowdria ruminantium in commercial beef enterprises in Zimbabwe was used to consider the potential impact of a candidate vaccine to prevent heartwater. The important characteristics of the vaccine were (1) a delay ...
As part of a series of studies associated with the development of improved vaccines for heartwater (a tick-borne disease of ruminant livestock caused by Cowdria ruminantium), field surveys were carried out to assess losses associated with the disease and the costs associated with controlling it i...
Heartwater, caused by the rickettsial organism Cowdria ruminantium, is a serious constraint to livestock development in much of sub-Saharan Africa. Traditionally, the disease has been controlled by the use of chemical acaricides to control the vector tick. The University of Florida/USAID-supporte...
Adult Amblyomma hebraeum ticks, the principle vector of heartwater (cowdriosis) of domestic ruminants in southern Africa, were collected in pheromone traps placed in Kruger National Park, an exclusively wildlife sanctuary in South Africa. These ticks transmitted Cowdria ruminantium, the rickettsi...
The authors highlight the reliance on repeated natural infections by tickborne pathogens to maintain immunity in immunized herds. That incidence of clinical heartwater in cattle, caused by Cowdria ruminantium, is low while intensive acaricide use interrupts transmission of pathogens. Evidence is ...
Analysis of the transmission dynamics of Cowdria ruminantium, the tick-borne rickettsial agent of heartwater in ruminants, requires accurate measures of infection in vector populations. To obtain these, Amblyomma hebraeum ticks were collected at two heartwater-endemic locations in the lowveld and...
In order to assess the economic impact of heartwater (Cowdria ruminantium infection) and model the impact of improved vaccines against the disease, a field study was conducted to provide data on livestock productivity indicators in Zimbabwe. Cross-sectional studies were performed in the two main ...
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