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Sheep has successfully adapted to the extreme high-altitude Himalayan region. To identify genes underlying such adaptation, we genotyped genome-wide single nucleotide polymorphisms (SNPs) of four major sheep breeds living at different altitudes in Nepal and downloaded SNP array data from addition...


Gorkhali, N.A.Kunzhe DongMin YangShen SongKader, A.Shrestha, B.S.Xiaohong HeQian-Jun ZhaoYabin PuXiangchen LiKijas, J.Weijun, GuanHan JianlinLin JiangYuehui Ma[Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas]Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas

Heteroplasmy due to length polymorphism with tandem repeats in mtDNAs within individual was hardly studied in domestic animals. In the present study, we identified intra-individual length variation in the control region of mtDNAs in Nepalese sheep by molecular cloning and sequencing techniques. W...


Gorkhali, N.A.Lin JiangShrestha, B.S.Xiao-Hong HeQian-Jun ZhaoHan JianlinYue-Hui Ma[High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep]High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep

MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles of developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in the sheep skeletal muscle ti...


Qian-Jun ZhaoYe KangHong-Yang WangWeijun, GuanXiang-Chen LiLin JiangXiao-Hong HeYabin PuHan JianlinYue-Hui MaQian-Jun Zhao[Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development]Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development

Despite much attention, history of sheep (Ovis aries) evolution, including its dating, demographic trajectory and geographic spread, remains controversial. To address these questions, we generated 45 complete and 875 partial mitogenomic sequences, and performed a meta-analysis of these and publis...


Feng-Hua LvWei-Feng PengJi YangYong-Xin ZhaoWen-Rong LiMing-Jun LiuYue-Hui MaQian-Jun ZhaoGuang-Li YangFeng WangJin-Quan LiYong-Gang LiuZhi-Qiang ShenSheng-Guo ZhaoEEr HehuaGorkhali, N.A.Farhad Vahidi, S.M.Muladno, M.Naqvi, A.N.Tabell, J.Iso-Touru, T.Bruford, M.W.Kantanen, J.Han JianlinMeng-Hua Li[Mitogenomic meta-analysis identifies two phases of migration in the history of Eastern Eurasian sheep]Mitogenomic meta-analysis identifies two phases of migration in the history of Eastern Eurasian sheep

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