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Signaling pathway alterations are important in the development of gastric cancer (GC). Deregulation of the PI3K/AKT/mTOR pathway plays a crucial role in the regulation of multiple cellular functions including cell growth, proliferation, metabolism, and angiogenesis. Our goal was to assess express...


Tapia, OscarRiquelme, IsmaelLeal, PamelaSandoval, AlejandraAedo, SusanaWeber, HelgaLetelier, PabloBellolio, EnriqueVillaseca, MiguelGarcia, PatriciaCarlos Roa, Juan[The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance]The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance

Reprimo (RPRM) is a potential p53-dependent tumor suppressor gene, which plays an important role in cell cycle arrest at G(2)/M checkpoint. The aim of this study was to characterize RPRM protein expression in breast cancer tissues and its relation with clinic-pathologic features and proliferation...


Buchegger, KurtLopez, JaimeIli, CarmenRiquelme, IsmaelLetelier, PabloGuzman, PabloBellolio, EnriqueCorvalan, Alejandro H.Brebi, PriscillaCarlos Roa, Juan[Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer]Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer
Buchegger, KurtIli, CarmenRiquelme, IsmaelLetelier, PabloCorvalan, Alejandro H.Brebi, PriscillaHuang, Tim Hui MingCarlos Roa, Juan[Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line]Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line
Letelier, PabloGuzman Oyarzo, NeftaliMedina Schwerter, GustavoCalcumil, LuisHuencho, PamelaMora, JonathanQuinones, FranciscoJara, JorgeReyno, CristobalFarias, Jorge G.Herrera Belen, BelenBrebi, PriscillaRiquelme, IsmaelSan Martin, Andres[WORKFLOW OPTIMIZATION IN A CLINICAL LABORATORY USING LEAN MANAGEMENT PRINCIPLES IN THE PRE-ANALYTICAL PHASE]WORKFLOW OPTIMIZATION IN A CLINICAL LABORATORY USING LEAN MANAGEMENT PRINCIPLES IN THE PRE-ANALYTICAL PHASE

Fucoidans are sulphated polysaccharides that can be obtained from brown seaweed and marine invertebrates. They have anti-cancer properties, through their targeting of several signaling pathways and molecular mechanisms within malignant cells. This review describes the chemical structure diversity...


Reyes, Maria ElenaRiquelme, IsmaelSalvo, TomasZanella, LouiseLetelier, PabloBrebi, Priscilla[Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance]Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance

Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer p...


Riquelme, IsmaelLetelier, PabloRiffo Campos, Angela L.Brebi, PriscillaCarlos Roa, Juan[Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer]Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer

Biliary tract cancers (BTCs) are a group of highly aggressive malignant tumors with a poor prognosis. The current diagnosis is based mainly on imaging and intraoperative exploration due to brush cytology having a low sensitivity and the standard markers, such as carcinoembryonic antigen (CEA) and...


Letelier, PabloRiquelme, IsmaelHernández Monsalves, AlfonsoGuzman Oyarzo, NeftaliFarias, Jorge G.Carlos Roa, Juan[Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers]Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers
Riquelme, IsmaelTapia, OscarLeal, PamelaSandoval, AlejandraVarga, Matthew G.Letelier, PabloBuchegger, KurtBizama, CarolinaEspinoza, Jaime A.Peek, Richard M.Carlos Araya, JuanCarlos Roa, Juan[miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway]miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway

Aims Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels of mucin 5B (MUC5B) and carbonic anhydrase 9 (CA9) were highly increased in...


Espinoza, Jaime A.Riquelme, IsmaelSagredo, Eduardo A.Rosa, LorenaGarcia, PatriciaBizama, CarolinaApud Bell, MariaLeal, PamelaWeber, HelgaBenavente Muñoz, FelipeVargas, SergioRomero, DiegoKalergis, Alexis M.Carlos Roa, Juan[Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma]Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which has given rise to a global sanitary emergency. The clinical characteristics of COVID-19 are varied and can range from an asymptomatic infection to a mild to severe pneumonia. Recent studies have shown that different laborator...


Letelier, PabloEncina, NicoleMorales, PabloRiffo, AlejandraSilva, HalettRiquelme, IsmaelGuzman Oyarzo, Neftali[ROLE OF BIOCHEMICAL MARKERS IN THE MONITORING OF COVID-19 PATIENTS]ROLE OF BIOCHEMICAL MARKERS IN THE MONITORING OF COVID-19 PATIENTS

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