Signaling pathway alterations are important in the development of gastric cancer (GC). Deregulation of the PI3K/AKT/mTOR pathway plays a crucial role in the regulation of multiple cellular functions including cell growth, proliferation, metabolism, and angiogenesis. Our goal was to assess express...
Tapia, Oscar
,
Riquelme, Ismael
,
Leal, Pamela
,
Sandoval, Alejandra
,
Aedo, Susana
,
Weber, Helga
,
Letelier, Pablo
,
Bellolio, Enrique
,
Villaseca, Miguel
,
Garcia, Patricia
,
Carlos Roa, Juan
,
[The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance]
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The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance
Reprimo (RPRM) is a potential p53-dependent tumor suppressor gene, which plays an important role in cell cycle arrest at G(2)/M checkpoint. The aim of this study was to characterize RPRM protein expression in breast cancer tissues and its relation with clinic-pathologic features and proliferation...
Buchegger, Kurt
,
Lopez, Jaime
,
Ili, Carmen
,
Riquelme, Ismael
,
Letelier, Pablo
,
Guzman, Pablo
,
Bellolio, Enrique
,
Corvalan, Alejandro H.
,
Brebi, Priscilla
,
Carlos Roa, Juan
,
[Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer]
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Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer
Buchegger, Kurt
,
Ili, Carmen
,
Riquelme, Ismael
,
Letelier, Pablo
,
Corvalan, Alejandro H.
,
Brebi, Priscilla
,
Huang, Tim Hui Ming
,
Carlos Roa, Juan
,
[Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line]
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Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line
Letelier, Pablo
,
Guzman Oyarzo, Neftali
,
Medina Schwerter, Gustavo
,
Calcumil, Luis
,
Huencho, Pamela
,
Mora, Jonathan
,
Quinones, Francisco
,
Jara, Jorge
,
Reyno, Cristobal
,
Farias, Jorge G.
,
Herrera Belen, Belen
,
Brebi, Priscilla
,
Riquelme, Ismael
,
San Martin, Andres
,
[WORKFLOW OPTIMIZATION IN A CLINICAL LABORATORY USING LEAN MANAGEMENT PRINCIPLES IN THE PRE-ANALYTICAL PHASE]
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WORKFLOW OPTIMIZATION IN A CLINICAL LABORATORY USING LEAN MANAGEMENT PRINCIPLES IN THE PRE-ANALYTICAL PHASE
Fucoidans are sulphated polysaccharides that can be obtained from brown seaweed and marine invertebrates. They have anti-cancer properties, through their targeting of several signaling pathways and molecular mechanisms within malignant cells. This review describes the chemical structure diversity...
Reyes, Maria Elena
,
Riquelme, Ismael
,
Salvo, Tomas
,
Zanella, Louise
,
Letelier, Pablo
,
Brebi, Priscilla
,
[Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance]
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Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance
Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer p...
Riquelme, Ismael
,
Letelier, Pablo
,
Riffo Campos, Angela L.
,
Brebi, Priscilla
,
Carlos Roa, Juan
,
[Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer]
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Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer
Biliary tract cancers (BTCs) are a group of highly aggressive malignant tumors with a poor prognosis. The current diagnosis is based mainly on imaging and intraoperative exploration due to brush cytology having a low sensitivity and the standard markers, such as carcinoembryonic antigen (CEA) and...
Letelier, Pablo
,
Riquelme, Ismael
,
Hernández Monsalves, Alfonso
,
Guzman Oyarzo, Neftali
,
Farias, Jorge G.
,
Carlos Roa, Juan
,
[Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers]
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Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers
Riquelme, Ismael
,
Tapia, Oscar
,
Leal, Pamela
,
Sandoval, Alejandra
,
Varga, Matthew G.
,
Letelier, Pablo
,
Buchegger, Kurt
,
Bizama, Carolina
,
Espinoza, Jaime A.
,
Peek, Richard M.
,
Carlos Araya, Juan
,
Carlos Roa, Juan
,
[miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway]
,
miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway
Aims Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels of mucin 5B (MUC5B) and carbonic anhydrase 9 (CA9) were highly increased in...
COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which has given rise to a global sanitary emergency. The clinical characteristics of COVID-19 are varied and can range from an asymptomatic infection to a mild to severe pneumonia. Recent studies have shown that different laborator...
Letelier, Pablo
,
Encina, Nicole
,
Morales, Pablo
,
Riffo, Alejandra
,
Silva, Halett
,
Riquelme, Ismael
,
Guzman Oyarzo, Neftali
,
[ROLE OF BIOCHEMICAL MARKERS IN THE MONITORING OF COVID-19 PATIENTS]
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ROLE OF BIOCHEMICAL MARKERS IN THE MONITORING OF COVID-19 PATIENTS