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Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system, maintenance of cell function and differentiation, epithelial surfa...


Bono, M.R.Tejon, G.Flores-Santibañez, FFernandez, D.Rosemblatt, M.Sauma, D.[Retinoic acid as a modulator of T cell immunity]Retinoic acid as a modulator of T cell immunity

Adoptive transfer of CD4+CD25+FOXP3+ regulatory T cells (Treg cells) has been successfully utilized to treat graft versus host disease and represents a promising strategy for the treatment of autoimmune diseases and transplant rejection. The aim of this study was to evaluate the effects of all-tr...


Candia, E.Reyes, P.Covian, C.Rodriguez, F.Wainstein, N.Morales, J.Mosso, C.Rosemblatt, M.Fierro, J.A.[Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells]Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells

Memory CD8+ T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8+ T cell effector subsets to persist and become memory cells has not been fully characterized. Type...


Flores-Santibáñez, F.Cuadra, B.Fernández, D.Rosemblatt, M.V.Núñez, S.Cruz, P.Gálvez-Cancino, F.César Cárdenas, J.Lladser, A.Rosemblatt, M.Bono, M.R.Sauma, D.[In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo]In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo

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