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A cross-sectional stratified random sample survey of 1755 households in the Kenya highlands was conducted between June 1996 and April 1998 to quantify cattle population dynamics in smallholder herds. The free-, semi-zero- and zero-grazing systems practised represented increasing levels of intensi...


Bebe, B.O.Udo, H.M.J.Rowlands, G.J.Thorpe, W.R.[Smallholder dairy systems in the Kenya highlands: cattle population dynamics under increasing intensification]Smallholder dairy systems in the Kenya highlands: cattle population dynamics under increasing intensification

In 1986 a project was set up to determine the constraints to production of Zebu cattle under trypanosomiasis risk in the Ghibe valley. Approximately 1800 East African Zebu cattle (EAZC) were resident within the Ghibe valleey during the experimental period (1986 - 1992) and were maintained under t...


Peregrine, A.S.Mulatu, W.Leak, S.G.A.Rowlands, G.J.[Epidemiology of bovine trypanosomiasis in the Ghibe Valley, Ethiopia: Multiple-drug resistance and its effective control]Epidemiology of bovine trypanosomiasis in the Ghibe Valley, Ethiopia: Multiple-drug resistance and its effective control

The objective of this study was to apply transition models to distinguish between factors associated with both incident and persistent trypanosome infections. Data collected from 1561 cattle were analyzed from a long-term study involving 8 herds in which both trypanosome infections (a total of 56...


Schukken, Y.H.Schaik, G. vanMcDermott, John J.Rowlands, G.J.Nagda, S.M.Mulatu, W.D'Ieteren, G.D.M.[Transition models to assess risk factors for new and persistent trypanosome infections in cattle - analysis of longitudinal data from the Ghibe Valley, Southwest Ethiopia]Transition models to assess risk factors for new and persistent trypanosome infections in cattle - analysis of longitudinal data from the Ghibe Valley, Southwest Ethiopia

A tsetse control campaign was started in January 1991 using a synthetic pyrethroid cypermethrin `pour-on' applied monthly to cattle exposed to high levels of drug-resistant trypanosomes in the Ghibe valley of southwest Ethiopia. In December 1992, a cost-recovery scheme was introduced, and thereaf...


Rowlands, G.J.Mulatu, W.Leak, S.G.A.Nagda, S.M.D'Ieteren, G.D.M.[Estimating the effects of tsetse control on livestock productivity - a case study in southwest Ethiopia]Estimating the effects of tsetse control on livestock productivity - a case study in southwest Ethiopia

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...


Iraqi, F.A.Sekikawa, K.Rowlands, G.J.Teale, A.J.[Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection]Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection

Full-length recombinant versions of p67, the 709 amino acid major surface protein of Theileria parva sporozoites, induce immunity to East Coast fever (ECF) in cattle. We show that a soluble Escherichia coli recombinant version of p67 (p67635), in which a prokaryotic signal peptide replaces the e...


Bishop, Richard P.Nene, VishvanathStaeyert, J.Rowlands, G.J.Nyanjui, J.Osaso, J.Morzaria, S.P.Musoke, A.J.[Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites]Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites

Two novel baculovirus-derived recombinant Theileria parva p67 constructs were tested for their vaccine potential against East Coast fever. Boran calves were immunized with a his-GFP-p67 fusion protein (GFP:p67DeltaSS) or with GP64:p67C, a protein fusion between a C-terminal domain of p67 and th...


Kaba, S.A.Musoke, A.J.Schaap, D.Schetters, T.Rowlands, G.J.Vermeulen, A.N.Nene, VishvanathVlak, J.M.Oers, M.M. van[Novel baculovirus-derived p67 subunit vaccines efficacious against East Coast fever in cattle]Novel baculovirus-derived p67 subunit vaccines efficacious against East Coast fever in cattle

A longitudinal study was carried out in the coastal lowlands coconut¯cassava agro-ecological zone of Kaloleni Division, Coast Province, Kenya between June 1990 and December 1991 to estimate disease incidence and cause-specific case-fatality risk in an average of 120 cattle in 26 small-holder dai...


Maloo, S.H.Rowlands, G.J.Thorpe, W.R.Gettinby, G.Perry, Brian D.[A longitudinal study of disease incidence and case fatality risks on smallholder dairy farms in coastal Kenya]A longitudinal study of disease incidence and case fatality risks on smallholder dairy farms in coastal Kenya

Two recombinant vaccines against Theileria parva, based on a near full-length version of the sporozoite surface antigen p67 (p67635), or an 80 amino acid C-terminal section (p67C), were evaluated by exposure of immunized cattle to natural tick challenge in two sites at the Kenya Coast and one i...


Musoke, A.J.Rowlands, G.J.Nene, VishvanathNyanjui, J.Katende, J.Spooner, P.R.Mwaura, S.Odongo, D.Nkonge, C.Mbogo, S.Bishop, Richard P.Morzaria, S.P.[Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge]Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge

A cross-sectional study was carried out from July to September 1989 in Kaloleni Division, Coast Province, Kenya to estimate the prevalence of vector-transmitted diseases in small-holder dairy cattle and to identify the risk factors associated with different management systems. One hundred and thi...


Maloo, S.H.Thorpe, W.R.Kiio, G.Ngumi, P.Rowlands, G.J.Perry, Brian D.[Seroprevalences of vector-transmitted infections of small-holder dairy cattle in coastal Kenya]Seroprevalences of vector-transmitted infections of small-holder dairy cattle in coastal Kenya

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