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Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe2+, biliverdin and CO. It has been shown that HMOX1 act...


Sebastián, V.P.Salazar, G.A.Coronado-Arrázola, I.Schultz, B.M.Vallejos, O.P.Berkowitz, L.Álvarez-Lobos, M.M.Riedel, C.A.Kalergis, A.M.Bueno, S.M.[Heme oxygenase-1 as a modulator of intestinal inflammation development and progression]Heme oxygenase-1 as a modulator of intestinal inflammation development and progression

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative bacterium that produces disease in numerous hosts. In mice, oral inoculation is followed by intestinal colonization and subsequent systemic dissemination, which leads to severe pathogenesis without the activation of an ef...


Salazar, G.A.Peñaloza, H.F.Pardo-Roa, C.Schultz, B.M.Muñoz-Durango, N.Gómez, R.S.Salazar, F.J.Pizarro, D.P.Riedel, C.A.González, P.A.Alvarez-Lobos, M.Kalergis, A.M.Bueno, S.M.[Interleukin-10 Production by T and B Cells Is a Key Factor to Promote Systemic Salmonella enterica Serovar Typhimurium Infection in Mice]Interleukin-10 Production by T and B Cells Is a Key Factor to Promote Systemic Salmonella enterica Serovar Typhimurium Infection in Mice

Chronic intestinal inflammations are triggered by genetic and environmental components. However, it remains unclear how specific changes in the microbiota, host immunity, or pathogen exposure could promote the onset and exacerbation of these diseases. Here, we evaluated whether Salmonella enteric...


Schultz, B.M.Salazar, G.A.Paduro, C.A.Pardo-Roa, C.Pizarro, D.P.Salazar-Echegarai, F.J.Torres, J.Riedel, C.A.Kalergis, A.M.Alvarez-Lobos, M.M.Bueno, S.M.[Persistent Salmonella enterica serovar Typhimurium infection increases the susceptibility of mice to develop intestinal inflammation]Persistent Salmonella enterica serovar Typhimurium infection increases the susceptibility of mice to develop intestinal inflammation

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