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Svitek, NicholasHansen, A.M.Steinaa, LucillaSaya, R.Awino, A.Nielsen, MortenBuus, SorenNene, Vishvanath[Immunoinformatics and MHC-Tetramers, revolutionary technologies for vaccine development]Immunoinformatics and MHC-Tetramers, revolutionary technologies for vaccine development
Svitek, NicholasSteinaa, LucillaSaya, R.Awino, EliasNielsen, MortenBuus, SorenNene, Vishvanath[The quest for the needle (antigen) in the haystack (pathogen): Immunoinformatics to the rescue]The quest for the needle (antigen) in the haystack (pathogen): Immunoinformatics to the rescue

Theileria parva is a protozoan parasite that causes the disease East Coast fever in cattle which results in major economic losses in Eastern, Central and Southern Africa. Efforts to generate vaccines involve measurements of cytotoxic activity since CD8 cells are believed to be responsible for pro...


Wendoh, J.Waihenya, R.Saya, R.Awino, EliasNene, VishvanathSteinaa, Lucilla[Perforin expression in Theileria parva specific Cytotoxic T Cells correlates with Cytotoxicity]Perforin expression in Theileria parva specific Cytotoxic T Cells correlates with Cytotoxicity

The protozoan parasite Theileria parva causes a usually fatal disease in cattle, known as East Coast fever. Cattle can be vaccinated by injecting live parasites simultaneously with long acting oxytetracycline (the Infection and Treatment Method, ITM). The immunity induced by ITM is believed to be...


Steinaa, LucillaSaya, R.Awino, EliasToye, Philip G.[Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen]Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen

Peptide-major histocompatibility complex (p-MHC) class I tetramer complexes have facilitated the early detection and functional characterisation of epitope specific CD8+ cytotoxic T lymphocytes (CTL). Here, we report on the generation of seven recombinant bovine leukocyte antigens (BoLA) and reco...


Svitek, NicholasHansen, A.M.Steinaa, LucillaSaya, R.Awino, EliasNielsen, MortenBuus, SorenNene, Vishvanath[Use of “one-pot, mix-and-read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle]Use of “one-pot, mix-and-read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle

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