Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-α (TNF-α), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia develop...
Naessens, Jan
,
Kitani, H.
,
Nakamura, Y.
,
Yagi, Y.
,
Sekikawa, K.
,
Iraqi, F.A.
,
[TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]
,
TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-alpha (TNF-alpha), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia...
Naessens, Jan
,
Kitani, H.
,
Nakamura, Y.
,
Yagi, Y.
,
Sekikawa, K.
,
Iraqi, F.A.
,
[TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]
,
TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survi...
Naessens, Jan
,
Kitani, H.
,
Momotani, E.
,
Sekikawa, K.
,
Nthale, J.M.
,
Iraqi, F.A.
,
[Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response]
,
Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response
C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-alpha) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-alpha genes was correlated with the capacity to control parasitaemia and ...
Naessens, Jan
,
Kitani, H.
,
Momotani, E.
,
Sekikawa, K.
,
Nthale, J.M.
,
Iraqi, F.A.
,
[Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response]
,
Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response
Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival...
The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to Trypanosoma congolense infection. To evaluate whether the HSP70.1 gene is involved in the response, we compared the susceptibility of HS...
Nakamura, Y.
,
Naessens, Jan
,
Takata, M.
,
Taniguchi, T.
,
Sekikawa, K.
,
Gibson, John P.
,
Iraqi, F.A.
,
[Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection]
,
Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection
Tumor necrosis factor-α (TNF-α) plays a role in the host’s defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can influence paras...
Kitani, H.
,
Yagi, Y.
,
Naessens, Jan
,
Sekikawa, K.
,
Iraqi, F.A.
,
[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene]
,
The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene
The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...
Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a role in the host's defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can inf...
Kitani, H.
,
Yagi, Y.
,
Naessens, Jan
,
Sekikawa, K.
,
Iraqi, F.A.
,
[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene]
,
The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene
A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populati...
Teale, A.J.
,
Agaba, Morris
,
Clapcott, S.J.
,
Gelhaus, A.
,
Haley, C.
,
Psifidis, A.
,
Horstmann, R.
,
Iraqui, F.
,
Kemp, Stephen J.
,
Nilsson, P.
,
Schwerin, M.
,
Sekikawa, K.
,
Soller, M.
,
Sugimoto, Y.
,
Womack, J.
,
[Resistance to trypanosomosis: Of markers, genes and mechanisms]
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Resistance to trypanosomosis: Of markers, genes and mechanisms