Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-α (TNF-α), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia develop...
Naessens, Jan
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Kitani, H.
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Nakamura, Y.
,
Yagi, Y.
,
Sekikawa, K.
,
Iraqi, F.A.
,
[TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]
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TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survi...
Naessens, Jan
,
Kitani, H.
,
Momotani, E.
,
Sekikawa, K.
,
Nthale, J.M.
,
Iraqi, F.A.
,
[Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response]
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Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response
Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival...