The main conclusion from the present study is that T. parva sporozoite entry is dependent on a functional host cell actin cytoskeleton and is not driven by the parasite. Treating lymphocytes with cytochalasin D resulted in a dose-dependent reduction in the levels of host cell infection. However, ...
Shaw, M.K.
,
[Theileria parva: Sporozoite entry into bovine lymphocytes is not dependent on the parasite cytoskeleton]
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Theileria parva: Sporozoite entry into bovine lymphocytes is not dependent on the parasite cytoskeleton
Shaw, M.K.
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Tilney, L.G.
,
[How individual cells develop from a syncytium: Merogony in Theileria parva (Apicomplexa)]
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How individual cells develop from a syncytium: Merogony in Theileria parva (Apicomplexa)
The major histocompatibility complex (MHC) class I molecules are ubiquious cell surface molecules involved in the cell-mediated immune response. We show here, using a number of different, independent approaches, that these proteins are an essential component of the host cell surface receptor invo...
Shaw, M.K.
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Tilney, L.G.
,
Musoke, A.J.
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Teale, A.J.
,
[MHC class I molecules are an essential cell surface component involved in Theileria parva sporozoite binding to bovine lymphocytes]
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MHC class I molecules are an essential cell surface component involved in Theileria parva sporozoite binding to bovine lymphocytes
Shaw, M.K.
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Tilney, L.G.
,
Musoke, A.J.
,
[The entry of Theileria parva sporozoites into bovine lymphocytes: Evidence for MHC class I involvement]
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The entry of Theileria parva sporozoites into bovine lymphocytes: Evidence for MHC class I involvement
The role of calcium in Theileria parva sporozoite entry into bovine lymphocytes was examined. Depletion of Ca2+ from the external medium had little effect on sporozoite entry suggesting that the initial sporozoite-host cell interaction is a Ca2+-independent process. Sporozoite entry could, howeve...
Shaw, M.K.
,
[Mobilization of intrasporozoite Ca(2+) is essential for Theileria parva sporozoite invasion of bovine lymphocytes]
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Mobilization of intrasporozoite Ca(2+) is essential for Theileria parva sporozoite invasion of bovine lymphocytes
Brown, W.C.
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Shaw, M.K.
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Conrad, P.A.
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Dolan, T.T.
,
[Theileria-parva: Reappearance of schizonts in infected lymphoblastoid cells treated with parvaquone is dependent on interleukin 2-like growth factors]
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Theileria-parva: Reappearance of schizonts in infected lymphoblastoid cells treated with parvaquone is dependent on interleukin 2-like growth factors
The initiation of feeding of infected Rhipicephalus appendiculatus adults induces the rapid development of Theileria parva sporoblasts within the salivary gland acini leading to the production of numerous sporozoites which are inoculated into the mammalian host initiating infection. In this study...
Shaw, M.K.
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Young, A.S.
,
[Differential development and emission of Theileria parva sporozoites from the salivary gland of Rhipicephalus appendiculatus]
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Differential development and emission of Theileria parva sporozoites from the salivary gland of Rhipicephalus appendiculatus
Sporozoite invasion of bovine lymphocytes by Theileria parva is a pH-dependent process that occurs without the need for de novo protein synthesis. The process was inhibited by RGD(S) peptides, fibronectin and, in the presence of serum, by antibodies reactive with fibronectin. Invasion was also bl...
Shaw, M.K.
,
[Characterization of the parasite-host cell interactions involved in Theileria parva sporozoite invasion of bovine lymphocytes]
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Characterization of the parasite-host cell interactions involved in Theileria parva sporozoite invasion of bovine lymphocytes
Shaw, M.K.
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Tilney, L.G.
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McKeever, Declan J.
,
[Tick salivary gland extract an interleukin-2 stimulation enhance susceptibility of lymphocytes to infection by Theileria parva sporozoites]
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Tick salivary gland extract an interleukin-2 stimulation enhance susceptibility of lymphocytes to infection by Theileria parva sporozoites
Stagg, D.A.
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Bishop, Richard P.
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Morzaria, S.P.
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Shaw, M.K.
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Wesonga, D.
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Orinda, G.O.
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Grootenhuis, J.G.
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Molyneux, D.H.
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Young, A.S.
,
[Characterization of Theileria parva which infects water buck (Kobus defassa)]
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Characterization of Theileria parva which infects water buck (Kobus defassa)