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Sileghem, M.R.Saya, R.Ellis, J.Flynn, J.N.Peel, J.E.Williams, D.J.L.[Detection and neutralization of bovine tumor necrosis factor by a monoclonal antibody]Detection and neutralization of bovine tumor necrosis factor by a monoclonal antibody

Murine models have suggested that CD8 T cells might play a major parasite-promoting role in African trypanosomiasis. To assess the role of these cells in a natural host environment, we have depleted CD8 cells from Boran cattle in vivo and subsequently infected these animals with Trypanosoma congo...


Sileghem, M.R.Naessens, Jan[Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment?]Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment?

Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differenc...


Naessens, JanTeale, A.J.Sileghem, M.R.[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]Identification of mechanisms of natural resistance to African trypanosomiasis in cattle
Ellis, J.A.Godson, D.Campos, M.Sileghem, M.R.Babiuk, L.A.[Capture immunoassay for ruminant tumor necrosis factor-alpha: Comparison with bioassay]Capture immunoassay for ruminant tumor necrosis factor-alpha: Comparison with bioassay

Immune mechanisms against Cowdria ruminantium infection in livestock hosts are being investigated. This knowledge will be important for identification of protective antigens of C. ruminantium which will have application in the Development of vaccines against heartwater. T-cell Con-A supernatants ...


Mahan, S.M.Sileghem, M.R.Smith, G.Byrom, B.[Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract]Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract

This paper determines whether tumour necrosis factor (TNF alpha) (a cytokine that is predominantly secreted by cells of the monocyte/macrophage lineage) production is induced during bovine trypanosomiasis and wheather or not production is correlated with disease. TNF alpha titres in plasma from B...


Sileghem, M.R.Gaidulis, L.[Production of tumour necrosis factor alpha during bovine trypanosomiasis: possible correlation with severity of anaemia associated with the disease]Production of tumour necrosis factor alpha during bovine trypanosomiasis: possible correlation with severity of anaemia associated with the disease

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