Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differen...
Naessens, Jan
,
Teale, A.J.
,
Sileghem, M.R.
,
[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]
,
Identification of mechanisms of natural resistance to African trypanosomiasis in cattle
Murine models have suggested that CD8 T cells might play a major parasite-promoting role in African trypanosomiasis. To assess the role of these cells in a natural host environment, we have depleted CD8 cells from Boran cattle in vivo and subsequently infected these animals with Trypanosoma congo...
Sileghem, M.R.
,
Naessens, Jan
,
[Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment?]
,
Are CD8 T cells involved in control of African trypanosomiasis in a natural host environment?
Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differenc...
Naessens, Jan
,
Teale, A.J.
,
Sileghem, M.R.
,
[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]
,
Identification of mechanisms of natural resistance to African trypanosomiasis in cattle
The membrane-associated form of the variable surface glycoprotein (mfVSG) from African trypanosomes is a potent macrophage activator capable of inducing production of tumor necrosis factor z (TNFalfa) in both bovine and murine models. Using a bovine model. we have re-investigated the hypothesis t...
Sileghem, M.R.
,
Saya, R.
,
Grab, D.J.
,
Naessens, Jan
,
[An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes]
,
An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes
Sileghem, M.R.
,
Flynn, J.N.
,
[Suppression of interleukin 2 secretion and interleukin 2 receptor expression during tsetse-transmitted trypanosomiasis in cattle]
,
Suppression of interleukin 2 secretion and interleukin 2 receptor expression during tsetse-transmitted trypanosomiasis in cattle
Sileghem, M.R.
,
Flynn, J.N.
,
[Involvement of gamma-delta T cells in immunity to trypanosomiasis]
,
Involvement of gamma-delta T cells in immunity to trypanosomiasis