ILRAD outlined two different areas of research concern to the trypanosomiasis program. One goal was to identify trypanosomal antigens responsible for the immunopathogenesis of the disease by determining how the infection of cattle with trypanosomes affects their immune system. A second goal was...
Darji, A.
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Lucas, R.
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Magez, S.
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Torreele, E.
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Palacios, J.
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Sileghem, M.R.
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Bajyana Songa, E.
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Hamers, R.
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Baetselier, P. de
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[Mechanisms underlying trypanosome-elicited immunosuppression]
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Mechanisms underlying trypanosome-elicited immunosuppression
Immune mechanisms against Cowdria ruminantium infection in livestock hosts are being investigated. This knowledge will be important for identification of protective antigens of C. ruminantium which will have application in the Development of vaccines against heartwater. T-cell Con-A supernatants ...
Mahan, S.M.
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Sileghem, M.R.
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Smith, G.
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Byrom, B.
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[Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract]
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Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract
Sileghem, M.R.
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Flynn, J.N.
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[Suppression of T-cell responsiveness during tsetse-transmitted trypanosomiasis in cattle]
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Suppression of T-cell responsiveness during tsetse-transmitted trypanosomiasis in cattle
In previous studies, the resistance to infection by Trypanosoma congolense has been localized in a region of chromosome 17 consisting the gene of TNF alpha. On the other hand, it has been Reported that the TNF alpha has a trypanolitic activity. So, we have started to study the expression of TN al...
Iraqi, F.A.
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Sileghem, M.R.
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Teale, A.J.
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[TNF-alpha expression in trypanosomiasis resistant and susceptible mouse strains during infection with Trypanosoma congolense]
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TNF-alpha expression in trypanosomiasis resistant and susceptible mouse strains during infection with Trypanosoma congolense
This paper determines whether tumour necrosis factor (TNF alpha) (a cytokine that is predominantly secreted by cells of the monocyte/macrophage lineage) production is induced during bovine trypanosomiasis and wheather or not production is correlated with disease. TNF alpha titres in plasma from B...
Sileghem, M.R.
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Gaidulis, L.
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[Production of tumour necrosis factor alpha during bovine trypanosomiasis: possible correlation with severity of anaemia associated with the disease]
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Production of tumour necrosis factor alpha during bovine trypanosomiasis: possible correlation with severity of anaemia associated with the disease