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Pavez, L.Tobar, N.Chacon, C.Arancibia, R.Martinez, C.Tapia, C.Pastor, A.Gonzalez, M.Martinez, J.Smith, P. C.[Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts]Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts

Gingival wound healing comprises a series of sequential responses that allow the closure of breaches in the masticatory mucosa. This process is of critical importance to prevent the invasion of microbes or other agents into tissues, avoiding the establishment of a chronic infection. Wound healing...


Smith, P. C.Caceres, M.Martinez, C.Oyarzun, A.Martinez, J.[Gingival Wound Healing: An Essential Response Disturbed by Aging?]Gingival Wound Healing: An Essential Response Disturbed by Aging?

Background and Objectives: Methylglyoxal is a toxic product derived from glucose metabolism that plays a role in inflammation, diabetes and aging. In addition, the periodontal pathogen Tannerella forsythensis may also generate this compound. However, the effects of methylglyoxal on gingival cells...


Retamal, I. N.Hernández, R.González-Rivas, C.Cáceres, M.Arancibia, R.Romero, A.Martínez, C.Tobar, N.Martínez, J.Smith, P. C.[Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells]Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells

Background: Plasma-derived fractions have been used as an autologous source of growth factors; however, limited knowledge concerning their biologic effects has hampered their clinical application. In this study, the authors analyze the content and specific effect of both platelet-rich plasma (PRP...


Martinez, C. E.Gonzalez, S. A.Palma, V.Smith, P. C.[Platelet-Poor and Platelet-Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells]Platelet-Poor and Platelet-Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells

Platelet degranulation allows the release of a large amount of soluble mediators, is an essential step for wound healing initiation, and stimulates clotting, and angiogenesis. The latter process is one of the most critical biological events observed during tissue repair, increasing the growth of ...


Martinez, C. E.Smith, P. C.Alvarado, V. A. P.[The influence of platelet-derived products on angiogenesis and tissue repair: a concise update]The influence of platelet-derived products on angiogenesis and tissue repair: a concise update

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