The ‘Muguga cocktail’ live vaccine, delivered by an infection and treatment protocol, has been widely deployed in Eastern, Central and Southern Africa to protect cattle against East Coast fever, caused by Theileria parva. The vaccine contains 3 component stocks (Muguga, Serengeti-transformed and ...
Oura, C.A.L.
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Bishop, Richard P.
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Asiimwe, B.B.
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Spooner, P.R.
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Lubega, G.W.
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Tait, A.
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[Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field]
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Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field
The 'Muguga cocktail' which is composed of three Theileria parva stocks Muguga. Kiambu 5 and Serengeti-transformed has been used extensively for live vaccination against East Coast fever in cattle in eastern, central and southern Africa. Herein we describe the molecular characterization of the T....
Bishop, Richard P.
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Geysen, D.
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Spooner, P.R.
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Skilton, Robert A.
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Nene, Vishvanath
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Dolan, T.T.
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Morzaria, S.P.
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[Molecular and immunological characterisation of Theileria parva stocks which are components of the Muguga cocktail used for vaccination against East Coast fever in cattle]
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Molecular and immunological characterisation of Theileria parva stocks which are components of the Muguga cocktail used for vaccination against East Coast fever in cattle
Two recombinant vaccines against Theileria parva, based on a near full-length version of the sporozoite surface antigen p67 (p67635), or an 80 amino acid C-terminal section (p67C), were evaluated by exposure of immunized cattle to natural tick challenge in two sites at the Kenya Coast and one i...
Musoke, A.J.
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Rowlands, G.J.
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Nene, Vishvanath
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Nyanjui, J.
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Katende, J.
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Spooner, P.R.
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Mwaura, S.
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Odongo, D.
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Nkonge, C.
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Mbogo, S.
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Bishop, Richard P.
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Morzaria, S.P.
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[Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge]
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Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge
The nucleotide sequences of the large subunit ribosomal RNA coding genes within the two single copy ribosomal DNA transcription units of a cloned Theileria parva isolate from a buffalo were determined. The two LSU rRNA coding units differed by 11 nucleotide substitutions and two deletions of 1 an...
Bishop, Richard P.
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Gobright, E.I.
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Spooner, P.R.
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Allsopp, B.A.
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Sohanpal, B.K.
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Collins, N.
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[Microsequence heterogeneity and expression of LSU rRNA genes within the two single copy ribosomal transcription units of Theileria parva]
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Microsequence heterogeneity and expression of LSU rRNA genes within the two single copy ribosomal transcription units of Theileria parva
Irvin, A.D.
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Ocama, J.G.R.
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Spooner, P.R.
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[Cycle of bovine lymphoblastoid cells parasitized by Theileria parva]
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Cycle of bovine lymphoblastoid cells parasitized by Theileria parva
Morzaria, S.P.
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Irvin, A.D.
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Taracha, E.A.
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Spooner, P.R.
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Voigt, W.P.
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Fujinaga, T.
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Katende, J.M.
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[Immunization against East Coast fever. The use of selected stocks of Theileria parva for immunization of cattle exposed to field challenge]
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Immunization against East Coast fever. The use of selected stocks of Theileria parva for immunization of cattle exposed to field challenge
The preparation of Theileria parva stabilates has been described by Cunningham et al (1973). The method is detailed in the FAO report (1978) and the FAO tick and tick-borne Disease Manual (1984). Theileria parva stabilates are a source of viable sporozoites that can be used to immunise cattle by ...
Morzaria, S.P.
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Spooner, P.R.
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Bishop, Richard P.
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Mwaura, S.
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[The preparation of a composite stabilate for immunisation against East Coast fever]
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The preparation of a composite stabilate for immunisation against East Coast fever
The current Infection and Treatment Method of vaccination against East Coast fever comprises an inoculation of live Theileria parva sporozoites and simultaneous administration of oxytetracycline. Immunization with a combination of parasite types has been shown to provide broader protection than i...
Patel, Ekta
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Lubembe, D.M.
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Gachanja, J.
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Mwaura, S.
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Spooner, P.R.
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Toye, Philip G.
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[Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity]
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Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity
Dobbelaere, D.A.E.
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Irvin, A.D.
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Spooner, P.R.
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Ocama, J.G.R.
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[Incorporation of 3H-hypoxanthine by Theileria parva during development in the feeding adult tick Rhipicephalus appendiculatus]
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Incorporation of 3H-hypoxanthine by Theileria parva during development in the feeding adult tick Rhipicephalus appendiculatus
Shapiro, S.Z.
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Fujisaki, K.
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Morzaria, S.P.
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Webster, P.
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Fujinaga, T.
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Spooner, P.R.
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Irvin, A.D.
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[A life-cycle stage-specific antigen of Theileria parva recognized by anti-macroschizont monoclonal antibodies]
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A life-cycle stage-specific antigen of Theileria parva recognized by anti-macroschizont monoclonal antibodies