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The ‘Muguga cocktail’ live vaccine, delivered by an infection and treatment protocol, has been widely deployed in Eastern, Central and Southern Africa to protect cattle against East Coast fever, caused by Theileria parva. The vaccine contains 3 component stocks (Muguga, Serengeti-transformed and ...


Oura, C.A.L.Bishop, Richard P.Asiimwe, B.B.Spooner, P.R.Lubega, G.W.Tait, A.[Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field]Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field

Theileria are tick-transmitted, haemoprotozoan parasites infecting wild and domestic ungulates throughout many areas of the world. The most economically important species are T. parva and T. annulata which are pathogenic to cattle, and T. lestoquardi (syn hirci) which is pathogenic to sheep and g...


Skilton, Robert A.Musoke, A.J.Nene, VishvanathWasawo, D.P.S.Wells, C.W.Spooner, P.R.Bishop, Richard P.Osaso, J.Nkonge, C.Latif, A.Morzaria, S.P.[Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen]Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen

The current Infection and Treatment Method of vaccination against East Coast fever comprises an inoculation of live Theileria parva sporozoites and simultaneous administration of oxytetracycline. Immunization with a combination of parasite types has been shown to provide broader protection than i...


Patel, EktaLubembe, D.M.Gachanja, J.Mwaura, S.Spooner, P.R.Toye, Philip G.[Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity]Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity

To identify the genes encoding novel immunodominant antigens of Theileria parvo a ?gt11 library of piroplasm genomic DNA was immunoscreened with bovine recovery serum and a gene encoding a 150 kDa antigen (p150) was identified. The predicted polypeptide contains an N-terminal secretory signal seq...


Skilton, Robert A.Bishop, Richard P.Wells, C.W.Spooner, P.R.Gobright, E.I.Nkonge, C.Musoke, A.J.Macklin, M.D.Iams, K.P.[Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)]Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)

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