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Bishop, Richard P.Sohanpal, B.K.Spooner, P.R.Dolan, T.T.Allsopp, B.A.Morzaria, S.P.[Detection of polymorphisms among Theileria parva stocks using repetitive, telomeric ribosomal DNA probes and anti-schizont monoclonal antibodies]Detection of polymorphisms among Theileria parva stocks using repetitive, telomeric ribosomal DNA probes and anti-schizont monoclonal antibodies

To identify the genes encoding novel immunodominant antigens of Theileria parvo a ?gt11 library of piroplasm genomic DNA was immunoscreened with bovine recovery serum and a gene encoding a 150 kDa antigen (p150) was identified. The predicted polypeptide contains an N-terminal secretory signal seq...


Skilton, Robert A.Bishop, Richard P.Wells, C.W.Spooner, P.R.Gobright, E.I.Nkonge, C.Musoke, A.J.Macklin, M.D.Iams, K.P.[Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)]Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)

Protective immunity induced by the infective sporozoite stage of Theileria parva indicates a potential role for antibodies directed against conserved serologically reactive regions of the major sporozoite surface antigen p67 in vaccination to control the parasite. We have examined the allelic var...


Obara, I.Ulrike, S.Musoke, A.J.Spooner, P.R.Jabbar, A.Odongo, D.Kemp, Stephen J.Silva, J.C.Bishop, Richard P.[Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva]Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva

Background Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod vector, which involves an obligate sexual cy...


Henson, S.Bishop, Richard P.Morzaria, S.P.Spooner, P.R.Pelle, RogerPoveda, L.Ebeling, M.Kung, E.Certa, U.Daubenberger, C.A.Weihong Qi[High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing]High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing

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