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East Coast fever (ECF) caused by Theileria parva kills cattle in East, Central and Southern Africa leading to significant economic losses. Vaccination is used as a control strategy against ECF and is presently dependent on deliberate infection with live sporozoites and simultaneous treatment with...


Nyagwange, JamesNene, VishvanathMwalimu, Stephen M.Henson, Sonal P.Steinaa, LucillaNzau, Benjamin M.Tijhaar, EdwinPelle, Roger[Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro]Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro

Objectives: The objective of this study was to assess whether cytotoxic T cells (CTL) generated by the live vaccine, known as “ITM Muguga cocktail”, which is used for the cattle disease East Cost fever (ECF) in Sub-Saharan Africa, showed a broad reactivity against many different strains of the ca...


Steinaa, LucillaSvitek, NicholasAwino, EliasSaya, RosemaryToye, Philip G.[Cytotoxic T lymphocytes from cattle sharing the same MHC class I haplotype and immunized with live Theileria parva sporozoites differ in antigenic specificity]Cytotoxic T lymphocytes from cattle sharing the same MHC class I haplotype and immunized with live Theileria parva sporozoites differ in antigenic specificity

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