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Journal Article 2018-05-01

Autor: Nyagwange, James Nene, Vishvanath Mwalimu, Stephen M. Henson, Sonal P. Steinaa, Lucilla Nzau, Benjamin M. Tijhaar, Edwin Pelle, Roger

East Coast fever (ECF) caused by Theileria parva kills cattle in East, Central and Southern Africa leading to significant economic losses. Vaccination is used as a control strategy against ECF and is presently dependent on deliberate infection with live sporozoites and simultaneous treatment with...

Enlace original: https://cgspace.cgiar.org/handle/10568/92522

Investigación en Agricultura
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Nyagwange, James ,  Nene, Vishvanath ,  Mwalimu, Stephen M. ,  Henson, Sonal P. ,  Steinaa, Lucilla ,  Nzau, Benjamin M. ,  Tijhaar, Edwin ,  Pelle, Roger ,  [Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro] ,  Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro
Journal Article 2018-05-02

Autor: Steinaa, Lucilla Svitek, Nichiolas Awino, Elias Njoroge, Thomas Saya, Rosemary M. Toye, Philip G.

Background The tick-borne protozoan parasite Theileria parva causes a usually fatal cattle disease known as East Coast fever in sub-Saharan Africa, with devastating consequences for poor small-holder farmers. Immunity to T. parva, believed to be mediated by a cytotoxic T lymphocyte (CTL) response...

Enlace original: https://cgspace.cgiar.org/handle/10568/96893

Investigación en Agricultura
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Steinaa, Lucilla ,  Svitek, Nichiolas ,  Awino, Elias ,  Njoroge, Thomas ,  Saya, Rosemary M. ,  Toye, Philip G. ,  [Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals] ,  Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals
Journal Article 2018-01-17

Autor: Steinaa, Lucilla Svitek, Nicholas Awino, Elias Saya, Rosemary Toye, Philip G.

Objectives: The objective of this study was to assess whether cytotoxic T cells (CTL) generated by the live vaccine, known as “ITM Muguga cocktail”, which is used for the cattle disease East Cost fever (ECF) in Sub-Saharan Africa, showed a broad reactivity against many different strains of the ca...

Enlace original: https://cgspace.cgiar.org/handle/10568/92437

Investigación en Agricultura
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Steinaa, Lucilla ,  Svitek, Nicholas ,  Awino, Elias ,  Saya, Rosemary ,  Toye, Philip G. ,  [Cytotoxic T lymphocytes from cattle sharing the same MHC class I haplotype and immunized with live Theileria parva sporozoites differ in antigenic specificity] ,  Cytotoxic T lymphocytes from cattle sharing the same MHC class I haplotype and immunized with live Theileria parva sporozoites differ in antigenic specificity
Journal Article 2016-06-15

Autor: Nene, Vishvanath Kiara, Henry K. Lacasta, Anna Pelle, Roger Svitek, Nicholas Steinaa, Lucilla

Tremendous progress has been made over the last ten years on East Coast fever (ECF) research. Publication of a reference genome sequence of Theileria parva, the causative agent of ECF, has led to a more thorough characterization of the genotypic and antigenic diversity of the pathogen. It also fa...

Enlace original: https://cgspace.cgiar.org/handle/10568/72680

Investigación en Agricultura
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Nene, Vishvanath ,  Kiara, Henry K. ,  Lacasta, Anna ,  Pelle, Roger ,  Svitek, Nicholas ,  Steinaa, Lucilla ,  [The biology of Theileria parva and control of East Coast fever—Current status and future trends] ,  The biology of Theileria parva and control of East Coast fever—Current status and future trends
Journal Article 2015-09-15

Autor: Svitek, Nicholas Awino, Elias Nene, Vishvanath Steinaa, Lucilla

We have recently shown that the BoLA-A18 variant haplotype (BoLA-6*01302) is more prevalent than the BoLA-A18 haplotype (BoLA-6*01301) in a sample of Holstein/Friesian cattle in Kenya. These MHC class I allelic variants differ by a single amino acid polymorphism (Glu97 to Leu97) in the peptide-bi...

Enlace original: https://cgspace.cgiar.org/handle/10568/67244

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Svitek, Nicholas ,  Awino, Elias ,  Nene, Vishvanath ,  Steinaa, Lucilla ,  [BoLA-6*01301 and BoLA-6*01302, two allelic variants of the A18 haplotype, present the same epitope from the Tp1 antigen of Theileria parva] ,  BoLA-6*01301 and BoLA-6*01302, two allelic variants of the A18 haplotype, present the same epitope from the Tp1 antigen of Theileria parva
Journal Article 2011-11

Autor: Koefoed, K. Steinaa, Lucilla Soderberg, J.N. Kjaer, I. Jacobsen, H.J. Meijer, P.-J. Haurum, J.S. Jensen, A. Kragh, M. Andersen, P.S. Pedersen, M.W.

The epidermal growth factor receptor (EGFR) is frequently dysregulated in human malignancies and a validated target for cancer therapy. Two monoclonal anti-EGFR antibodies (cetuximab and panitumumab) are approved for clinical use. However, the percentage of patients responding to treatment is low...

Enlace original: https://cgspace.cgiar.org/handle/10568/35344

Investigación en Agricultura
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Koefoed, K. ,  Steinaa, Lucilla ,  Soderberg, J.N. ,  Kjaer, I. ,  Jacobsen, H.J. ,  Meijer, P.-J. ,  Haurum, J.S. ,  Jensen, A. ,  Kragh, M. ,  Andersen, P.S. ,  Pedersen, M.W. ,  [Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor] ,  Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor
Journal Article 2010-12-08

Autor: Lantto, J. Hansen, M.H. Rasmussen, S.K. Steinaa, Lucilla Poulsen, T.R. Duggan, J. Dennis, M. Naylor, I. Easterbrook, L. Bregenholt, S. Haurum, J. Jensen, A.

The eradication of smallpox (variola) and the subsequent cessation of routine vaccination have left modern society vulnerable to bioterrorism employing this devastating contagious disease. The existing, licensed vaccines based on live vaccinia virus (VACV) are contraindicated for a substantial nu...

Enlace original: https://cgspace.cgiar.org/handle/10568/35251

Investigación en Agricultura
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Lantto, J. ,  Hansen, M.H. ,  Rasmussen, S.K. ,  Steinaa, Lucilla ,  Poulsen, T.R. ,  Duggan, J. ,  Dennis, M. ,  Naylor, I. ,  Easterbrook, L. ,  Bregenholt, S. ,  Haurum, J. ,  Jensen, A. ,  [Capturing the natural diversity of the human antibody response against vaccinia virus] ,  Capturing the natural diversity of the human antibody response against vaccinia virus
Journal Article 2015-04-30

Autor: Svitek, Nicholas Nzau, Benjamin M. Steinaa, Lucilla Nene, Vishvanath

We have developed a polymerase chain reaction-sequence-specific primers-restriction fragment length polymorphism (PCR-SSP-RFLP) method to rapidly differentiate between the A18 and A18 variant (v) BoLA haplotypes and between A14 and A15/A15v BoLA haplotypes in Holstein/Friesian cattle. We used pub...

Enlace original: https://cgspace.cgiar.org/handle/10568/66014

Investigación en Agricultura
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Svitek, Nicholas ,  Nzau, Benjamin M. ,  Steinaa, Lucilla ,  Nene, Vishvanath ,  [A method to discriminate between closely related bovine major histocompatibility complex class I alleles by combining established PCR-SSP assays with RFLPs] ,  A method to discriminate between closely related bovine major histocompatibility complex class I alleles by combining established PCR-SSP assays with RFLPs
Journal Article 2014-09-23

Autor: Wendoh, J. Waihenya, R. Saya, R. Awino, Elias Nene, Vishvanath Steinaa, Lucilla

Theileria parva is a protozoan parasite that causes the disease East Coast fever in cattle which results in major economic losses in Eastern, Central and Southern Africa. Efforts to generate vaccines involve measurements of cytotoxic activity since CD8 cells are believed to be responsible for pro...

Enlace original: https://cgspace.cgiar.org/handle/10568/56588

Investigación en Agricultura
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Wendoh, J. ,  Waihenya, R. ,  Saya, R. ,  Awino, Elias ,  Nene, Vishvanath ,  Steinaa, Lucilla ,  [Perforin expression in Theileria parva specific Cytotoxic T Cells correlates with Cytotoxicity] ,  Perforin expression in Theileria parva specific Cytotoxic T Cells correlates with Cytotoxicity
Journal Article 2012-02-15

Autor: Steinaa, Lucilla Saya, R. Awino, Elias Toye, Philip G.

The protozoan parasite Theileria parva causes a usually fatal disease in cattle, known as East Coast fever. Cattle can be vaccinated by injecting live parasites simultaneously with long acting oxytetracycline (the Infection and Treatment Method, ITM). The immunity induced by ITM is believed to be...

Enlace original: https://cgspace.cgiar.org/handle/10568/16380

Investigación en Agricultura
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Steinaa, Lucilla ,  Saya, R. ,  Awino, Elias ,  Toye, Philip G. ,  [Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen] ,  Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen

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