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Journal Article 2011-04-29

Autor: Pelle, Roger Graham, S.P. Njahira, Moses N. Osaso, J. Saya, R.M. Odongo, David O. Toye, Philip G. Spooner, P.R. Musoke, A.J. Mwangi, D.M. Taracha, E.L.N. Morrison, W. Ivan Weir, W. Silva, J. Bishop, Richard P.

Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...

Enlace original: https://cgspace.cgiar.org/handle/10568/3780

Investigación en Agricultura
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Pelle, Roger ,  Graham, S.P. ,  Njahira, Moses N. ,  Osaso, J. ,  Saya, R.M. ,  Odongo, David O. ,  Toye, Philip G. ,  Spooner, P.R. ,  Musoke, A.J. ,  Mwangi, D.M. ,  Taracha, E.L.N. ,  Morrison, W. Ivan ,  Weir, W. ,  Silva, J. ,  Bishop, Richard P. ,  [Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity] ,  Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity
Journal Article 2008-07-15

Autor: Jores, Joerg Nkando, I. Sterner-Kock, Anja Haider, W. Poole, Elizabeth J. Unger, H. Muriuki, C. Wesonga, H.O. Taracha, E.L.N.

Contagious bovine pleuropneumonia (CBPP) is a lung disease caused by the bacterial pathogen Mycoplasma mycoides ssp. mycoides small colony type (MmmSC). It has been spreading due to a number of factors including poor vaccine efficacy and poor sensitivity of current diagnostic tests. The purpose o...

Enlace original: https://cgspace.cgiar.org/handle/10568/1573

Investigación en Agricultura
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Jores, Joerg ,  Nkando, I. ,  Sterner-Kock, Anja ,  Haider, W. ,  Poole, Elizabeth J. ,  Unger, H. ,  Muriuki, C. ,  Wesonga, H.O. ,  Taracha, E.L.N. ,  [Assessment of in vitro interferon-gamma responses from peripheral blood mononuclear cells of cattle infected with Mycoplasma mycoides ssp. mycoides small colony type] ,  Assessment of in vitro interferon-gamma responses from peripheral blood mononuclear cells of cattle infected with Mycoplasma mycoides ssp. mycoides small colony type
Journal Article 2005-08-19

Autor: Bishop, Richard P. Shah, Tushaar Pelle, Roger Hoyle, D. Pearson, T. Haines, L. Brass, A. Hulme, H. Graham, S.P. Taracha, E.L.N. Lu, C. Hass, B. Wortman, J. White, O. Gardner, M.J. Nene, Vishvanath Villiers, Etienne P. de

Massively parallel signature sequencing (MPSS) was used to analyze the transcriptome of the intracellular protozoan Theileria parva. In total 1 095 000, 20 bp sequences representing 4371 different signatures were generated from T.parva schizonts. Reproducible signatures were identified within 73%...

Enlace original: https://cgspace.cgiar.org/handle/10568/21180

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Bishop, Richard P. ,  Shah, Tushaar ,  Pelle, Roger ,  Hoyle, D. ,  Pearson, T. ,  Haines, L. ,  Brass, A. ,  Hulme, H. ,  Graham, S.P. ,  Taracha, E.L.N. ,  Lu, C. ,  Hass, B. ,  Wortman, J. ,  White, O. ,  Gardner, M.J. ,  Nene, Vishvanath ,  Villiers, Etienne P. de ,  [Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage] ,  Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage
Journal Article 2007-02-09

Autor: Graham, S.P. Honda, Y. Pelle, Roger Mwangi, D.M. Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Bruggen, P. van der Nene, Vishvanath Taracha, E.L.N.

Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development ...

Enlace original: https://cgspace.cgiar.org/handle/10568/1394

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Graham, S.P. ,  Honda, Y. ,  Pelle, Roger ,  Mwangi, D.M. ,  Glew, E.J. ,  Villiers, Etienne P. de ,  Shah, Tushaar ,  Bishop, Richard P. ,  Bruggen, P. van der ,  Nene, Vishvanath ,  Taracha, E.L.N. ,  [A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology] ,  A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology
Journal Article 1999

Autor: Daubenberger, C.A. Taracha, E.L.N. Gaidulis, L. Davis, W.C. McKeever, Declan J.

T cells bearing the gamma delta antigen receptor (gamma delta T cells) can constitute up to 50 percent of T cells in the peripheral blood and lymphoid organs of young cattle. We present data showing that gamma delta T cells are involved in immune responses against Theileria parva. Gamma delta T c...

Enlace original: https://cgspace.cgiar.org/handle/10568/28767

Investigación en Agricultura
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Daubenberger, C.A. ,  Taracha, E.L.N. ,  Gaidulis, L. ,  Davis, W.C. ,  McKeever, Declan J. ,  [Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva] ,  Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva
Journal Article 2001

Autor: Ballingall, K.T. MacHugh, Niall D. Taracha, E.L.N. Mertens, B. McKeever, B.D.

Dendritic cells (DC) constitute the most effective immune cell population for priming and recalling T cell responses to foreign antigens. DC patrol the peripheral tissues collecting foreign antigen for subsequent presentation by classical class II MHC molecules to T cells in the draining lymph no...

Enlace original: https://cgspace.cgiar.org/handle/10568/32905

Investigación en Agricultura
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Ballingall, K.T. ,  MacHugh, Niall D. ,  Taracha, E.L.N. ,  Mertens, B. ,  McKeever, B.D. ,  [Transcription of the unique ruminant class II major histocompatibility complex-DYA and DIB genes in dendritic cells] ,  Transcription of the unique ruminant class II major histocompatibility complex-DYA and DIB genes in dendritic cells
Journal Article 2009-09-15

Autor: MacHugh, Niall D. Connelley, T. Graham, S.P. Pelle, Roger Formisano, P. Taracha, E.L.N. Ellis, S.A. McKeever, Declan J. Burrells, A. Morrison, W. Ivan

Although immunodominance of CD8+ T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear. In previous studies we have observed that CD8+ T-cell responses to Theileria parva exhibit different patterns of parasit...

Enlace original: https://cgspace.cgiar.org/handle/10568/342

Investigación en Agricultura
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MacHugh, Niall D. ,  Connelley, T. ,  Graham, S.P. ,  Pelle, Roger ,  Formisano, P. ,  Taracha, E.L.N. ,  Ellis, S.A. ,  McKeever, Declan J. ,  Burrells, A. ,  Morrison, W. Ivan ,  [CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity] ,  CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity
Journal Article 1998

Autor: Honda, Y. Waithaka, M.M. Taracha, E.L.N. Duchateau, L. Musoke, A.J. McKeever, Declan J.

To evaluate vaccinia virus as a delivery system for recombinant antigen in cattle, calves were immunized with a recombinant vaccinia virus (rVV) expressing the sporozoite surface antigen (p67) of Theileria parva (V-67) combined with those expressing bovine IL-4 (V-IL4) or IL-2 (V-IL2). The anti-p...

Enlace original: https://cgspace.cgiar.org/handle/10568/29820

Investigación en Agricultura
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Honda, Y. ,  Waithaka, M.M. ,  Taracha, E.L.N. ,  Duchateau, L. ,  Musoke, A.J. ,  McKeever, Declan J. ,  [Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection] ,  Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection
Journal Article 1998

Autor: Heussler, V.T. Taracha, E.L.N. Musoke, A.J. Duchateau, L. McKeever, Declan J.

Cattle immunised with a recombinant form of p67, the major surface antigen of Theilleria parva sporozoites, have been shown to be protected against parasite challenge. In an attempt to simplify the immunisation procedure live attenuated Salmonella strains expressing p67 have been constructed and ...

Enlace original: https://cgspace.cgiar.org/handle/10568/35341

Investigación en Agricultura
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Heussler, V.T. ,  Taracha, E.L.N. ,  Musoke, A.J. ,  Duchateau, L. ,  McKeever, Declan J. ,  [Immunisation with live attenuated Salmonella dublin expressing a sporozoite protein confers partial protection against Theileria parva] ,  Immunisation with live attenuated Salmonella dublin expressing a sporozoite protein confers partial protection against Theileria parva
Journal Article 2008-02-15

Autor: Akoolo, L. Pelle, Roger Saya, R. Awino, Elias Nyanjui, J. Taracha, E.L.N. Kanyari, P. Mwangi, D.M. Graham, S.P.

East Coast fever (ECF) is a highly fatal lymphoproliferative disease of cattle caused by Theileria parva, a tick-borne intracellular apicomplexan parasite. Parasite antigens that are targets of protective cytotoxic T lymphocyte (CTL) responses are required to formulate a sub-unit vaccine against ...

Enlace original: https://cgspace.cgiar.org/handle/10568/1942

Investigación en Agricultura
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Akoolo, L. ,  Pelle, Roger ,  Saya, R. ,  Awino, Elias ,  Nyanjui, J. ,  Taracha, E.L.N. ,  Kanyari, P. ,  Mwangi, D.M. ,  Graham, S.P. ,  [Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle] ,  Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle

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