Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...
Pelle, Roger
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Graham, S.P.
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Njahira, Moses N.
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Osaso, J.
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Saya, R.M.
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Odongo, David O.
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Toye, Philip G.
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Spooner, P.R.
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Musoke, A.J.
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Mwangi, D.M.
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Taracha, E.L.N.
,
Morrison, W. Ivan
,
Weir, W.
,
Silva, J.
,
Bishop, Richard P.
,
[Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity]
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Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity
Contagious bovine pleuropneumonia (CBPP) is a lung disease caused by the bacterial pathogen Mycoplasma mycoides ssp. mycoides small colony type (MmmSC). It has been spreading due to a number of factors including poor vaccine efficacy and poor sensitivity of current diagnostic tests. The purpose o...
Jores, Joerg
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Nkando, I.
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Sterner-Kock, Anja
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Haider, W.
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Poole, Elizabeth J.
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Unger, H.
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Muriuki, C.
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Wesonga, H.O.
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Taracha, E.L.N.
,
[Assessment of in vitro interferon-gamma responses from peripheral blood mononuclear cells of cattle infected with Mycoplasma mycoides ssp. mycoides small colony type]
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Assessment of in vitro interferon-gamma responses from peripheral blood mononuclear cells of cattle infected with Mycoplasma mycoides ssp. mycoides small colony type
Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development ...
Graham, S.P.
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Honda, Y.
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Pelle, Roger
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Mwangi, D.M.
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Glew, E.J.
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Villiers, Etienne P. de
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Shah, Tushaar
,
Bishop, Richard P.
,
Bruggen, P. van der
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Nene, Vishvanath
,
Taracha, E.L.N.
,
[A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology]
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A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology
Theileria parva antigens recognized by cytotoxic T lymphocytes (CTLs) are prime vaccine candidates against East Coast Fever in cattle. A strategy for enhancing induction of parasite-specific T cell responses by increasing recruitment and activation of dendritic cells (DCs) at the immunization sit...
Mwangi, D.M.
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Honda, Y.
,
Graham, S.P.
,
Pelle, Roger
,
Taracha, E.L.N.
,
Gachanja, J.
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Nyanjui, J.K.
,
Bray, J.
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Palmer, G.H.
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Brown, W.C.
,
Mwangi, W.
,
[Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses]
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Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses
Taracha, E.L.N.
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Irvin, A.D.
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Morzaria, S.P.
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Moloo, S.K.
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Katende, J.M.
,
Kiarie, J.N.
,
[Effect of chronic trypanosomiasis on immunization against East Coast fever]
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Effect of chronic trypanosomiasis on immunization against East Coast fever
The relationship of strain specificity of class I major histocompatibility complex-restricted parasite-specific cytotoxic T lymphocytes (CTL) responses and cross-protection was investigated in an effort to verify the role of CTL in protection. The parasite strain specificity of the CTL responses ...
Taracha, E.L.N.
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Goddeeris, B.M.
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Morzaria, S.P.
,
Morrison, W. Ivan
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[Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva]
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Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva
The importance of T-cell-mediate immune responses in the control of intracellular protozoan parasites is now well established 1-3. The killing of parasitized cells by T cells and cytokine-mediated effects on growth and viability of the intracellular parasites have both been implicated as effector...
Morrison, W. Ivan
,
Taracha, E.L.N.
,
McKeever, Declan J.
,
[Contribution of T-cell responses to immunity and pathogenesis in infection with Theileria parva]
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Contribution of T-cell responses to immunity and pathogenesis in infection with Theileria parva
Morzaria, S.P.
,
Irvin, A.D.
,
Voigt, W.P.
,
Taracha, E.L.N.
,
[Effect of timing and intensity of challenge following immunization against East Coast fever]
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Effect of timing and intensity of challenge following immunization against East Coast fever
The parasite strain specificity of CTL responses to Theileria parva varies among cattle immunized with the same parasite stock. We have investigated the influence of class I MHC on the strain specificity of CTL responses to T. parva in 19 cattle of defined class I phenotype immunized with either ...
Taracha, E.L.N.
,
Goddeeris, B.M.
,
Teale, A.J.
,
Kemp, Stephen J.
,
Morrison, W. Ivan
,
[Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance]
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Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance