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Journal Article 2005-08-19

Autor: Bishop, Richard P. Shah, Tushaar Pelle, Roger Hoyle, D. Pearson, T. Haines, L. Brass, A. Hulme, H. Graham, S.P. Taracha, E.L.N. Lu, C. Hass, B. Wortman, J. White, O. Gardner, M.J. Nene, Vishvanath Villiers, Etienne P. de

Massively parallel signature sequencing (MPSS) was used to analyze the transcriptome of the intracellular protozoan Theileria parva. In total 1 095 000, 20 bp sequences representing 4371 different signatures were generated from T.parva schizonts. Reproducible signatures were identified within 73%...

Enlace original: https://cgspace.cgiar.org/handle/10568/21180

Investigación en Agricultura
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Bishop, Richard P. ,  Shah, Tushaar ,  Pelle, Roger ,  Hoyle, D. ,  Pearson, T. ,  Haines, L. ,  Brass, A. ,  Hulme, H. ,  Graham, S.P. ,  Taracha, E.L.N. ,  Lu, C. ,  Hass, B. ,  Wortman, J. ,  White, O. ,  Gardner, M.J. ,  Nene, Vishvanath ,  Villiers, Etienne P. de ,  [Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage] ,  Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage
Journal Article 1999

Autor: Daubenberger, C.A. Taracha, E.L.N. Gaidulis, L. Davis, W.C. McKeever, Declan J.

T cells bearing the gamma delta antigen receptor (gamma delta T cells) can constitute up to 50 percent of T cells in the peripheral blood and lymphoid organs of young cattle. We present data showing that gamma delta T cells are involved in immune responses against Theileria parva. Gamma delta T c...

Enlace original: https://cgspace.cgiar.org/handle/10568/28767

Investigación en Agricultura
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Daubenberger, C.A. ,  Taracha, E.L.N. ,  Gaidulis, L. ,  Davis, W.C. ,  McKeever, Declan J. ,  [Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva] ,  Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva
Journal Article 1998

Autor: Honda, Y. Waithaka, M.M. Taracha, E.L.N. Duchateau, L. Musoke, A.J. McKeever, Declan J.

To evaluate vaccinia virus as a delivery system for recombinant antigen in cattle, calves were immunized with a recombinant vaccinia virus (rVV) expressing the sporozoite surface antigen (p67) of Theileria parva (V-67) combined with those expressing bovine IL-4 (V-IL4) or IL-2 (V-IL2). The anti-p...

Enlace original: https://cgspace.cgiar.org/handle/10568/29820

Investigación en Agricultura
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Honda, Y. ,  Waithaka, M.M. ,  Taracha, E.L.N. ,  Duchateau, L. ,  Musoke, A.J. ,  McKeever, Declan J. ,  [Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection] ,  Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection
Report 1994

Autor: Goddeeris, B.M. Morrison, W. Ivan Taracha, E.L.N. McKeever, Declan J.
Enlace original: https://cgspace.cgiar.org/handle/10568/49959

Investigación en Agricultura
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Goddeeris, B.M. ,  Morrison, W. Ivan ,  Taracha, E.L.N. ,  McKeever, Declan J. ,  [East Coast Fever (Theileria parva). Cell-mediated immunity and protection] ,  East Coast Fever (Theileria parva). Cell-mediated immunity and protection
Journal Article 2008-02-15

Autor: Akoolo, L. Pelle, Roger Saya, R. Awino, Elias Nyanjui, J. Taracha, E.L.N. Kanyari, P. Mwangi, D.M. Graham, S.P.

East Coast fever (ECF) is a highly fatal lymphoproliferative disease of cattle caused by Theileria parva, a tick-borne intracellular apicomplexan parasite. Parasite antigens that are targets of protective cytotoxic T lymphocyte (CTL) responses are required to formulate a sub-unit vaccine against ...

Enlace original: https://cgspace.cgiar.org/handle/10568/1942

Investigación en Agricultura
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Akoolo, L. ,  Pelle, Roger ,  Saya, R. ,  Awino, Elias ,  Nyanjui, J. ,  Taracha, E.L.N. ,  Kanyari, P. ,  Mwangi, D.M. ,  Graham, S.P. ,  [Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle] ,  Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle
Journal Article 2009-03-15

Autor: Graham, S.P. Pelle, Roger Villiers, Etienne P. de Yamage, M. Mwangi, D.M. Honda, Y. Ellis, S.A. MacHugh, Niall D. Morrison, W. Ivan Taracha, E.L.N.

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated through the destruction of parasite infected lymphocytes by MHC class I restricted CD8+ CTL. Six parasite proteins targeted by CTL from T. parva immune cattle have been identified and raised...

Enlace original: https://cgspace.cgiar.org/handle/10568/32

Investigación en Agricultura
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Graham, S.P. ,  Pelle, Roger ,  Villiers, Etienne P. de ,  Yamage, M. ,  Mwangi, D.M. ,  Honda, Y. ,  Ellis, S.A. ,  MacHugh, Niall D. ,  Morrison, W. Ivan ,  Taracha, E.L.N. ,  [Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva] ,  Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva
Journal Article 2006

Autor: Casanova, C.L. Xue, G. Taracha, E.L.N. Dobbelaere, D.A.E.

The presence of the schizont stage of the obligate intracellular parasites Theileria parva or T. annulata in the cytoplasm of an infected leukocyte results in host cell transformation via a mechanism that has not yet been elucidated. Proteins, secreted by the schizont, or expressed on its surface...

Enlace original: https://cgspace.cgiar.org/handle/10568/33057

Investigación en Agricultura
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Casanova, C.L. ,  Xue, G. ,  Taracha, E.L.N. ,  Dobbelaere, D.A.E. ,  [Post-translational signal peptide cleavage controls differential epitope recognition in the QP-rich domain of recombinant Theileria parva PIM] ,  Post-translational signal peptide cleavage controls differential epitope recognition in the QP-rich domain of recombinant Theileria parva PIM
Journal Article 2007

Autor: Graham, S.P. Saya, R. Awino, Elias Ngugi, D. Nyanjui, J.K. Hecker, R. Taracha, E.L.N. Nene, Vishvanath

Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymor...

Enlace original: https://cgspace.cgiar.org/handle/10568/33218

Investigación en Agricultura
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Graham, S.P. ,  Saya, R. ,  Awino, Elias ,  Ngugi, D. ,  Nyanjui, J.K. ,  Hecker, R. ,  Taracha, E.L.N. ,  Nene, Vishvanath ,  [Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva] ,  Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva
Journal Article 1999

Autor: McKeever, Declan J. Taracha, E.L.N. Morrison, W. Ivan Musoke, A.J. Morzaria, S.P.

Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understandin...

Enlace original: https://cgspace.cgiar.org/handle/10568/33104

Investigación en Agricultura
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McKeever, Declan J. ,  Taracha, E.L.N. ,  Morrison, W. Ivan ,  Musoke, A.J. ,  Morzaria, S.P. ,  [Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies] ,  Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies
Journal Article 2000

Autor: Ballingall, K.T. Mwangi, D.M. MacHugh, Niall D. Taracha, E.L.N. Totte, P. McKeever, Declan J.

We describe a highly sensitive, non-radioactive assay for T cell activation, based on the rapid induction of class II MHC expression by constitutively negative bovine endothelial cells, when cultured in the presence of supernatants derived from activated bovine T cells. We demonstrate the effecti...

Enlace original: https://cgspace.cgiar.org/handle/10568/33010

Investigación en Agricultura
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Ballingall, K.T. ,  Mwangi, D.M. ,  MacHugh, Niall D. ,  Taracha, E.L.N. ,  Totte, P. ,  McKeever, Declan J. ,  [A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells] ,  A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells

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